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An official publication of the Middle-Eastern Association for Cancer Research
Clinical Cancer Investigation Journal
ISSN Print: 2278-1668, Online: 2278-0513
ARTICLE
Year: 2018   |   Volume: 7   |   Issue: 1   |   Page: 1-8     View issue

Clinicopathological attributes of T-lymphoblastic lymphoma seen in a tertiary care centre


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Abstract

Background and Aims: T-lymphoblastic lymphoma (T-LBL) is a type of non-Hodgkin lymphoma (NHL), the cell of origin being the precursor T cell. This study was undertaken to describe the distribution, clinical presentation, morphological spectrum, immunohistochemical profile, and outcomes in patients with LBL presenting to our institution which is a tertiary care center. Methods: A total of 41 cases of T-LBL diagnosed during a 7-year period were included in this study. These patients were stratified into T-LBL cases and T-LBL/acute lymphoblastic leukemia cases, the latter defined as those with a lymphomatous mass and more than 25% blasts in the bone marrow. Medical records were reviewed for clinical, laboratory data, imaging findings, treatment, and follow-up. The histopathology and immunohistochemistry slides were reviewed. Results: T-LBL constituted 8.4% of all NHL seen in the period. This lymphoma is most common in childhood and adolescence. Mediastinal compression and pleural effusion are very common in patients with T-LBL (65% and 40%, respectively). The morphology consists of small-to-medium sized blasts that typically are positive for CD3, CD99, and TdT. T-LBL is an aggressive disease; relapse and progression being markers of poor outcome. Conclusion: This study is a comprehensive account of T-LBL from a tertiary care center in South India which describes the distribution, clinicopathological attributes and outcome in patients with this aggressive form of NHL.

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Vancouver
Mathan L, Ananthamurthy A. Clinicopathological attributes of T-lymphoblastic lymphoma seen in a tertiary care centre. Clin Cancer Investig J. 2018;7(1):1-8. https://doi.org/10.4103/ccij.ccij_67_17
APA
Mathan, L., & Ananthamurthy, A. (2018). Clinicopathological attributes of T-lymphoblastic lymphoma seen in a tertiary care centre. Clinical Cancer Investigation Journal, 7(1), 1-8. https://doi.org/10.4103/ccij.ccij_67_17

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ISSN Print: 2278-1668, Online: 2278-0513