Clinical Cancer Investigation Journal

REVIEW ARTICLE
Year
: 2021  |  Volume : 10  |  Issue : 2  |  Page : 53--59

Role of altered fractionation in radiation therapy with or without chemotherapy in management of carcinoma cervix: Time to revisit in the current COVID-19 pandemic


Deepak Kumar Agrawal1, Neha Agrawal2, Sovan Sarangdhar3, Vinita Kumari5, Narvada Narain5, Neelam Lader5, Sanjog Pal5, Satyajit Pradhan5 
1 Department of Radiation Oncology, Max Hospital and MICC, Shalimar Bagh, New Delhi; Department of Radiotherapy and Radiation Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
2 Department of Obs and Gyne, Baba Ambedkar Medical College and Hospital, New Delhi, India
3 Department of Radiotherapy and Radiation Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh; Department of Radiation Oncology, All India Institute of Medicla Sciences, Bhubaneswar, Odisha, India

Correspondence Address:
Deepak Kumar Agrawal
Department of Radiation Oncology, Max Hosital and Micc, Shalimar Bagh, New Delhi-110085
India

Severe acute respiratory syndrome coronavirus 2 as COVID-19 virus has affected the entire world and so to the cancer care and health-care facility. Cancer cervix is one of the common malignancies among women in developing and underdeveloped countries. Various challenges are being faced by patients and health-care providers to deliver optimal treatment under prescribed time frame. Faster delivery of whole treatment is desirable in the current pandemic. Overall treatment time in cancer cervix has prognostic value. Adoption of altered fractionation to delivered external beam radiation therapy could be a method for faster delivery of whole treatment. Altered fractionation such as hyperfractionation (HFX), hypofractionation, and accelerated fraction alone or with HFX has already been experimented for the past three decades. The total duration of treatment has been significantly reduced without addition of much toxicity. Few studies had also highlighted the feasibility of addition of chemotherapy to such fractionation schedule. However, prospective studies are still warranted to generate data to further support its use in the future.


How to cite this article:
Agrawal DK, Agrawal N, Sarangdhar S, Kumari V, Narain N, Lader N, Pal S, Pradhan S. Role of altered fractionation in radiation therapy with or without chemotherapy in management of carcinoma cervix: Time to revisit in the current COVID-19 pandemic.Clin Cancer Investig J 2021;10:53-59


How to cite this URL:
Agrawal DK, Agrawal N, Sarangdhar S, Kumari V, Narain N, Lader N, Pal S, Pradhan S. Role of altered fractionation in radiation therapy with or without chemotherapy in management of carcinoma cervix: Time to revisit in the current COVID-19 pandemic. Clin Cancer Investig J [serial online] 2021 [cited 2021 Jun 18 ];10:53-59
Available from: https://www.ccij-online.org/article.asp?issn=2278-0513;year=2021;volume=10;issue=2;spage=53;epage=59;aulast=Agrawal;type=0