Clinical Cancer Investigation Journal

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 4  |  Issue : 5  |  Page : 610--616

Concurrent cisplatin-based chemotherapy versus radiotherapy alone as adjuvant therapy for squamous cell carcinoma of the oral cavity bearing high-risk features


Anis Bandyopadhyay1, Surendranath Senapati2, Deepti Rani Samanta3, Sarthak Mohanty4, Prafulla Kumar Das5 
1 Department of Radiotherapy, Medical College and Hospital, Kolkata, West Bengal, India
2 Department of Radiation Oncology, Acharya Harihar Regional Cancer Center, Cuttack, Odisha, India
3 Department of Medical Oncology, Acharya Harihar Regional Cancer Center, Cuttack, Odisha, India
4 Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, Maharashtra, India
5 Department of Surgical Oncology, Acharya Harihar Regional Cancer Center, Cuttack, Odisha, India

Correspondence Address:
Anis Bandyopadhyay
Department of Radiotherapy, Medical College and Hospital, College Street, Kolkata, West Bengal, India.
India

Background: To compare concurrent cisplatin-based chemoradiation in an adjuvant setting for high-risk squamous cell carcinoma of oral cavity terms of toxicity, local-regional control, and overall survival. Materials and Methods: A total of 54 patients of postoperative squamous cell carcinoma of oral cavity with high-risk features were randomized into two groups; postoperative radiation (60 Gy/30#/6 weeks) or postoperative concurrent chemoradiation (60 Gy/30#/6 weeks with weekly concurrent cisplatin 50 mg) arms. Results: Buccal mucosa was the most common sub site (44.4%) affected, followed by lower alveolus/alveolar ridge (37%) and most tumors (64.3%) were well-differentiated. About 67.3% of the patients completed their course of radiation within 6 weeks with only 69 patients receiving the scheduled 60 Gy of external beam radiation therapy dose. Only 6 patients out of 22 completed the 6 cycles of weekly chemotherapy with compliance decreasing most after 3 cycles. Mucositis and dysphagia were significantly higher in the chemoradiation arm. After a median follow-up of 47 months, the loco-regional control rate was 51.4% in the postoperative chemoradiation arm as compared to 35.56% in the postoperative radiation arm. The 5 years overall survival was 56.4% in postoperative chemoradiation arm as compared to 51.3% in the postoperative radiation only. Conclusion: Postoperative concurrent chemoradiation with weekly cisplatin in high-risk oral cancer gave an advantage in the loco-regional control rate and overall survival at the end of 47 months, with significant increase in acute toxicities Grade III and Grade IV toxicities.


How to cite this article:
Bandyopadhyay A, Senapati S, Samanta DR, Mohanty S, Das PK. Concurrent cisplatin-based chemotherapy versus radiotherapy alone as adjuvant therapy for squamous cell carcinoma of the oral cavity bearing high-risk features.Clin Cancer Investig J 2015;4:610-616


How to cite this URL:
Bandyopadhyay A, Senapati S, Samanta DR, Mohanty S, Das PK. Concurrent cisplatin-based chemotherapy versus radiotherapy alone as adjuvant therapy for squamous cell carcinoma of the oral cavity bearing high-risk features. Clin Cancer Investig J [serial online] 2015 [cited 2021 Apr 21 ];4:610-616
Available from: https://www.ccij-online.org/article.asp?issn=2278-0513;year=2015;volume=4;issue=5;spage=610;epage=616;aulast=Bandyopadhyay;type=0