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LETTER TO EDITOR
Year : 2021  |  Volume : 10  |  Issue : 6  |  Page : 336

Platelet endothelial aggregation receptor 1 polymorphisms and idiopathic thrombocytopenic purpura


1 Private Academic Consultant, Bangkok, Thailand
2 Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India

Date of Submission29-Oct-2021
Date of Acceptance01-Nov-2021
Date of Web Publication11-Dec-2021

Correspondence Address:
Rujittika Mungmunpuntipantip
Private Academic Consultant, Bangkok
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ccij.ccij_108_21

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How to cite this article:
Mungmunpuntipantip R, Wiwanitkit V. Platelet endothelial aggregation receptor 1 polymorphisms and idiopathic thrombocytopenic purpura. Clin Cancer Investig J 2021;10:336

How to cite this URL:
Mungmunpuntipantip R, Wiwanitkit V. Platelet endothelial aggregation receptor 1 polymorphisms and idiopathic thrombocytopenic purpura. Clin Cancer Investig J [serial online] 2021 [cited 2022 Jan 27];10:336. Available from: https://www.ccij-online.org/text.asp?2021/10/6/336/332331



Dear Editor,

We would like to share ideas on the publication “Role of platelet endothelial aggregation receptor 1 polymorphisms in idiopathic thrombocytopenic purpura: Is there an association?[1]” Najafi et al. concluded that “There was no association between rs12041331 and rs12566888 with platelet parameters in ITP patients and the severity of …….[1]” In fact, the platelet endothelial aggregation receptor 1 polymorphism results in a molecular change and might further affect biological interaction. However, there are also other confounding factors, including other genetic polymorphisms, which can affect phenotypic expression in idiopathic thrombocytopenic purpura (ITP). Examples of other genetic polymorphisms that might affect ITP are D28, ICOS, PD1, TNFSF4, DNAM1, TIM3, CTLA4, and LAG polymorphisms.[2] Further studies to assess effect of other confounding genetic factors are interesting.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Najafi S, Jalali Far MA, Kaydani GA, Jaseb K, Saki N. Role of platelet endothelial aggregation receptor 1 polymorphisms in idiopathic thrombocytopenic purpura: Is there an association? Clin Cancer Investig J 2021;10:227-33.  Back to cited text no. 1
  [Full text]  
2.
Wang S, Zhang X, Leng S, Xu Q, Sheng Z, Zhang Y, et al. Immune checkpoint-related gene polymorphisms are associated with primary immune thrombocytopenia. Front Immunol 2020;11:615941.  Back to cited text no. 2
    




 

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