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 Table of Contents  
LETTER TO EDITOR
Year : 2021  |  Volume : 10  |  Issue : 1  |  Page : 51-52

Thoracoabdominal flap: A simple reconstruction technique for chest wall osteoradionecrosis


1 Department of Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India
2 Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India

Date of Submission11-Aug-2020
Date of Decision10-Oct-2020
Date of Acceptance16-Oct-2020
Date of Web Publication19-Feb-2021

Correspondence Address:
Navin Kumar
Flat No. 255, Type 3, A V Nagar, New Delhi - 110 049
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ccij.ccij_121_20

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How to cite this article:
Kumar N, Lata K, Deo S V. Thoracoabdominal flap: A simple reconstruction technique for chest wall osteoradionecrosis. Clin Cancer Investig J 2021;10:51-2

How to cite this URL:
Kumar N, Lata K, Deo S V. Thoracoabdominal flap: A simple reconstruction technique for chest wall osteoradionecrosis. Clin Cancer Investig J [serial online] 2021 [cited 2021 Mar 5];10:51-2. Available from: https://www.ccij-online.org/text.asp?2021/10/1/51/309796



Dear Editor,

Reconstruction of the irradiated chest wall after surgery is often a challenge due to the scarce amount of nonirradiated tissue availability and restricted vascularization.[1] The surgical treatment of osteoradionecrosis (ORN) primarily aims to eliminate infection, to excise all damaged tissue, and to provide chest wall stability. There are several options to correct these defects including skin grafts, local flaps such as transverse rectus abdominis muscle flap, latissimus dorsi muscle flap, rigid chest wall reconstruction, and even healing by secondary intention[1],[2] We present a reconstruction through a thoracoabdominal transposition flap that allows us to preserve the original anatomy of the region.

A 73-years-old female was diagnosed with left breast carcinoma, cT2N0M0 and underwent breast conservation surgery with axillary lymph node dissection and received adjuvant brachytherapy 20 Grays, 2 fractions approximately 20 years back. After approximately 10 years of disease-free interval, she developed a nonhealing ulcer at the inframammary crease of the ipsilateral breast. The ulcer did not heal with conservative treatment and gradually increased to the size of approximately 3.5 cm × 3.0 cm with necrotic slough on the ulcer base [Figure 1]a. Whole-body positron-emission tomography/computed tomography revealed speculate ulcer of size 1.6 cm × 2.4 cm × 3.5 cm (maximum standard uptake value – 1.89), suspicious of inflammatory (?), or recurrent (?) lesion. Histopathological examination (HPE) revealed irregular acanthotic epidermis, mild dermal inflammatory infiltrate, fibrosis, and fibrinous exudate with no evidence of recurrent malignancy, suggestive of ORN. Wide local excision with underlying ribs sequestrectomy was done with gross margins of 1 cm all round. A postoperative defect of size 6.0 cm × 5.0 cm × 3.0 cm was formed [Figure 1]b. The defect was reconstructed with the thoracoabdominal flap [Figure 1]c. The specimen was sent for HPE [Figure 1]d. The patient recovered uneventfully. HPE was consistent with similar initial pathological findings.
Figure 1: The nonhealing ulcer with necrotic slough on the base (a), postoperative wound defect (b), thoracoabdominal flap reconstruction (c), and surgical specimen (d)

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Chest wall ORN is an extremely rare radiation-induced toxicity. Hypoxia, hypovascularity, and hypocellularity due to radiation-induced free radicals are responsible for it.[3] The differentiation of ORN from recurrence is critical for the clinician. Biopsy of wound edge rules out the tumor recurrence. ORN heals spontaneously with secondary intention usually.[4] However, surgical debridement with en bloc resection of affected tissues followed by reconstruction with nonirradiated tissue is warranted in selected patients.[5] A transposition flap is defined as a flap that should be elevated over a normal skin area to reach its eventual primary defect destination. This reconstruction through a thoracoabdominal transposition flap allows preserving breast anatomy and its natural contour. It also provides skin with a similar color and texture to the defect, as an alternative to the free flap. Furthermore, it is a better surgical option than second-intention closure that is a long time-consuming healing process associated with a high chance of infection. The flap is well vascularized and consists of well-vascularized nonirradiated tissue. This surgical technique is a single-stage procedure and it provides a satisfactory cosmetic to the patient. The prognosis of ORN after flap reconstruction is excellent. The clinicians should be aware of such rare adverse events of brachytherapy.

In conclusion, we report a case of ORN of the chest wall after brachytherapy for breast cancer. It highlights this uncommon complication. The time interval to diagnosis is typically greater than a decade after the primary treatment. Surgical resection with nonirradiated local or distant flap reconstruction is the well-proven treatment for the potential cure in patients who do not respond with conservative management. Thoracoabdominal flap reconstruction is a simple, single-stage, and reliable surgical technique with a shallow learning curve.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient (s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initial s will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Raz DJ, Clancy SL, Erhunmwunsee LJ. Surgical management of the radiated chest wall and its complications. Thorac Surg Clin 2017;27:171-9.  Back to cited text no. 1
    
2.
Larson DL, McMurtrey MJ, Howe HJ, Irish CE. Major chest wall reconstruction after chest wall irradiation. Cancer 1982;49:1286-93.  Back to cited text no. 2
    
3.
Asai K, Shioyama Y, Nakamura K, Sasaki T, Ohga S, Nonoshita T, et al. Radiation-induced rib fractures after hypofractionated stereotactic body radiation therapy: Risk factors and dose-volume relationship. Int J Radiat Oncol Biol Phys 2012;84:768-73.  Back to cited text no. 3
    
4.
Meric F, Buchholz TA, Mirza NQ, Vlastos G, Ames FC, Ross MI, et al. Long-term complications associated with breast-conservation surgery and radiotherapy. Ann Surg Oncol 2002;9:543-9.  Back to cited text no. 4
    
5.
Sanna S, Brandolini J, Pardolesi A, Argnani D, Mengozzi M, Dell'Amore A, et al. Materials and techniques in chest wall reconstruction: A review. J Vis Surg 2017;3:95.  Back to cited text no. 5
    


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