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Year : 2020  |  Volume : 9  |  Issue : 4  |  Page : 99-106

Does human papillomavirus have any association with human colorectal cancer? A brief and critical review of the existing literature

Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

Correspondence Address:
Yasir Hameed
Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ccij.ccij_45_20

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Background: The role of human papillomavirus (HPV) has already been well-studied in colorectal cancer (CRC) with conflicting results. We performed a comprehensive review of the results and methodologies used in different previous studies that associated HPV with CRC, and evaluated that how well these studies fulfill the proposed criteria for proving HPV etiology in CRC. Methodology: The PubMed search engine was used to retrieve all the research articles published before March 2020 to detect HPV in CRC. Results: In total, 40 relevant original articles were found on PubMed. Some of them were case–control studies that compared the cancerous tissue samples with the normal or benign and some were not. The positivity ratios of HPV detection was varied population -wise. In some populations, it was greater in cancerous tissue samples as compared to the normal or benign tissues, whereas in other cases, the opposite situation was also observed. A 0% HPV detection positivity ratio in cancerous as well normal or benign samples was also observed in a few cases. However, the odds ratios and confidence intervals were not reported. Conclusion: The results of the present study are controversial. They failed to prove the potential participation of HPV in CRC but rather suggested it as cause-effective or at least a coparticipant in the pathogenesis of CRC.

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