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Year : 2019  |  Volume : 8  |  Issue : 6  |  Page : 257-260

Squash cytology of langerhans cell histiocytosis of sellar region

Department of Pathology, Shri Dharmasthala Manjunatheshwara College of Medical Sciences and Hospital, Sattur, Dharwad, Karnataka, India

Correspondence Address:
Supriya Verma
Officers' Mess, MH Shimla, Jutogh Cantt, Shimla - 171 008, Himachal Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ccij.ccij_66_19

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Langerhans cell histiocytosis (LCH) is a systemic disease, which usually involves the skeleton and skin of children with occasional involvement of the central nervous system (hypothalamo–pituitary axis). We report the case of a 16-year-old male with a space-occupying lesion (SOL) in the sellar region and diabetes insipidus. However, no systemic abnormality was noted. A clinical diagnosis of pituitary adenoma was given. However, on intraoperative consultation by squash smears, cells with nuclear grooves and few eosinophils were seen. Hence, a differential diagnosis of LCH was also given, which was confirmed by histopathology and immunohistochemistry. Hence, as a matter of fact, LCH should be considered as one of the rare differential diagnoses of SOL of sellar region.

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