Submit Your Article CMED MEACR meeting
Home Print this page Email this page Users Online: 96
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2016  |  Volume : 5  |  Issue : 5  |  Page : 441-446

Evaluation of stromal myofibroblasts in epithelial dysplasia and oral squamous cell carcinoma: An immunohistochemical study


1 Department of Oral Pathology and Microbiology, Vasantdada Patil Dental College and Hospital, Sangli, Maharashtra, India
2 Department of Oral Pathology and Microbiology, MGV's Dental College and Hospital, Nashik, Maharashtra, India

Correspondence Address:
Priya Shirish Joshi
B-3, Avani Apartment, 80 Feet Road, Datta Nagar, Vishrambag, Sangli - 416 415, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-0513.197886

Rights and Permissions

Background: Among the cancers, oral cancer occupies tenth position, and the incidence is rising alarmingly with more than 300,000 new cases being detected every year. The expression of myofibroblast (MF) has been demonstrated in various malignant lesions and is considered an important participant in the invasive process. We have attempted to analyze the distribution and possible association of MF in epithelial dysplasia and squamous cell carcinoma by immunohistochemistry. Materials and Methods: Histopathologically confirmed twenty cases each of epithelial dysplasia and oral squamous cell carcinoma and ten cases of normal mucosa comprised the study group. MFs were detected by immunostaining with alpha-smooth muscle actin (α-SMA). Blood vessels and normal oral mucosa acted as an internal and external control respectively. Results: Of twenty cases of epithelial dysplasia, six (30%) were positive, all cases of squamous cell carcinoma and normal mucosa were positive and negative for α-SMA expression respectively. No statistical significance was observed between the patterns of MF distribution. Statistically significant results of α-SMA expression were noted in severe grades of dysplasia (P = 0.000) and between epithelial dysplasia and squamous cell carcinoma (P = 0.000). Conclusion: Analysis of α-SMA expression for MF proliferation can be used as a stromal marker for predicting behavior in oral precancer and cancer.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1630    
    Printed28    
    Emailed0    
    PDF Downloaded15    
    Comments [Add]    
    Cited by others 2    

Recommend this journal