Submit Your Article CMED MEACR meeting
Home Print this page Email this page Users Online: 54
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2016  |  Volume : 5  |  Issue : 5  |  Page : 430-436

Immunohistochemical characterization of molecular classification of breast carcinoma and its relation with Ki-67


1 Department of Pathology, Lady Hardinge Medical College, New Delhi, India
2 Department of Pathology, M.R. Medical College, Gulbarga, Karnataka, India

Correspondence Address:
Shabnam Karangadan
Department of Pathology, Lady Hardinge Medical College, New Delhi - 110 001
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-0513.197876

Rights and Permissions

Background: Breast carcinoma is the leading cause of cancer deaths in women. Molecular classification of breast carcinoma along with Ki-67 index is considered a better predictive factor for prognosis and treatment than routine histopathology. Aims: To classify breast carcinoma into the four molecular subtypes defined by immunohistochemical expression of triple markers: Luminal A (estrogen receptor/progesterone receptor-positive [ER/PR+] and human epidermal growth factor receptor 2 HER2/neu), luminal B (ER/PR + and HER2/neu+), triple negative (ER/PR − and HER2/neu−), and HER2 positive (ER/PR−, HER2/neu+), and to correlate the expression of ER, PR, HER2/neu, and classification with Ki-67. Materials and Methods: The present study includes sixty breast carcinoma cases studied over a 3-year period. The expression patterns of ER, PR, HER2/neu, and Ki-67 were studied. Clinical features, pathologic features such as size, grade, and lymph node status, and correlation with Ki-67 of the four subtypes were compared. Results: Out of sixty cases, most common molecular subtype was triple negative (40.00%) followed by luminal B (23.33%). Most of the tumors showed low proliferative index (low Ki-67); however, triple negative and HER2 positive subtype showed high proliferative index. Most common histological subtype was ductal carcinoma which was mainly triple negative. All medullary carcinoma cases were triple negative. One case of lobular carcinoma and mucinous carcinoma each was HER2 positive and luminal B, respectively. Single case of carcinoma of male breast was luminal B subtype. Conclusion: Correlation of molecular classification with age, histological grade, and Ki-67 was statistically significant (P < 0.05). ER/PR also correlated with histological grade and Ki-67 (P < 0.01). These results emphasize the fact that molecular subtypes correlate with prognosis and aid in targeted therapy.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3726    
    Printed73    
    Emailed0    
    PDF Downloaded16    
    Comments [Add]    
    Cited by others 1    

Recommend this journal