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Year : 2015  |  Volume : 4  |  Issue : 3  |  Page : 458-461

Squamous cell carcinoma with osteoclast-like giant cells masquerading as pleomorphic sarcoma: A rare case report

1 Department of Pathology, Army Hospital Research and Referral, Delhi Cantonment, New Delhi, India
2 Department of Otolaryngology, Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India

Correspondence Address:
Khushboo Dewan
26, Amit Apartments, Sector 13, Rohini, New Delhi - 110 085
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2278-0513.148945

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Squamous cell carcinoma (SCC) with osteoclast-like giant cells (OLGCs) is a rare entity known to occur in skin, breast, lung, and pharynx. Only a single case of SCC containing OLGC in larynx has been reported so far. We report a case of a 65-year-old male patient presenting with sudden onset respiratory distress, who was subjected to biopsy, which was reported as undifferentiated sarcoma which was endorsed on laryngectomy specimen, however, sections from cervical lymph nodes revealed deposits of SCC. Extensive resectioning revealed a single focus showing origin of poorly differentiated carcinoma from the overlying squamous epithelium. Hence in undifferentiated pleomorphic sarcoma, a thorough sectioning and careful search for SCC including immunohistochemical markers should be done to exclude the possibility of a poorly differentiated epithelial malignancy.

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