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CASE REPORT
Year : 2015  |  Volume : 4  |  Issue : 3  |  Page : 435-437

Retinal detachment as the inaugural manifestation in Waldenstrom's macroglobulinemia


1 Department of Pathology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
2 Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India

Correspondence Address:
Namrata Nonavinakere Rajkumar
Department of Pathology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-0513.154536

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Waldenstrom's macroglobulinemia (WM) is a rare disorder and forms 1-2% of hematological malignancies. Rarely retinal detachment precedes the diagnosis of WM. In this case report, we present 65-year-old man with retinal detachment as the inaugural manifestation in WM. Clinical manifestations in WM are related to direct tumor infiltration, circulating immunoglobulin M (IgM) and deposition into tissues, amyloidogenic properties and autoantibody activity of IgM. Diagnosis is difficult, when a rare disease manifests differently, as in our case. Delay in diagnosis can be prevented by heightened awareness of this rare disease.


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