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ORIGINAL ARTICLE
Year : 2015  |  Volume : 4  |  Issue : 3  |  Page : 312-317

Diagnostic sensitivity of serum carcinoembryonic antigen, carbohydrate antigen 19-9, alpha-fetoprotein, and beta-human chorionic gonadotropin in esophageal carcinoma (receiver operating characteristic curve analysis)


1 Department of Biochemistry, SDM Hospital, Jaipur, India
2 Department of Pathology, SMS Medical College and Hospital, Jaipur, India
3 Department of Biochemistry, Mahatma Gandhi Medical College and Hospital, Jaipur, India
4 Department of Radiotherapy and Oncology, SMS Medical College and Hospital, Jaipur, India

Correspondence Address:
Bhawna Bagaria
Department of Biochemistry, SDM Hospital, Mansarovar, Jaipur
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-0513.154279

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Background: Esophageal carcinomas are very lethal disease relatively unresponsive to therapy. The continued development of new and more effective chemotherapeutic agents and regimens offers hope that in the future, this carcinoma may be amenable to either more effective palliative treatment or possibly increased cure. We, therefore, aimed to evaluate the marker with best diagnostic sensitivity in esophageal carcinoma. Materials and Methods: Serum carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9), alpha-fetoprotein (AFP), and beta-human chorionic gonadotropin (β-HCG) levels were assessed in healthy subjects (n = 50) and patients (n = 50) initially diagnosed of esophageal carcinoma by endoscopic examination and biopsy before receiving any therapy. The data were analyzed using SPSS software version 10.0 (SPSS Inc. USA) and MedCalc to estimate mean ± standard deviation, the significance of the observed differences (P value), for calculating sensitivity and for plotting receiver operating characteristic curves. Results: Sensitivity of CEA, CA19-9, AFP, and β-HCG detected in esophagus cancer was 38%, 18%, 10%, and 26% respectively. Conclusion: From the above studied markers, CEA has the highest sensitivity followed by β-HCG, CA19-9 and AFP. Although the sensitivity of tumor markers in esophagus cancer is low, they may be useful additional parameter in the prediction of neoplasms involved at the early stage of tumor growth.


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