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  Indian J Med Microbiol
 

Figure 1: Row 1 (left to right): (1) Moderately differentiated squamous cell carcinoma showing keratinization and intercellular bridges (H and E, ×40). (2) Well differentiated squamous cell carcinoma showing keratinization and intercellular bridges (H and E, ×40). (3) Moderately differentiated squamous cell carcinoma (MDSCC) showing strong expression of COX-2 with strong intensity in 50%–75% cells (Immunohistochemical score 3 × 3 = 9) (IHC, ×40). (4) Moderately differentiated squamous cell carcinoma (MDSCC) showing strong expression of COX-2 with strong intensity in 50%–75% cells (Immunohistochemical score 3 × 3 = 9) (IHC, ×40). (5) Well-differentiated squamous cell carcinoma showing strong expression COX-2 staining (Immunohistochemical score 3 × 4 = 12) (IHC, ×40). Row 2 (left to right): (6) Poorly differentiated squamous cell carcinoma (PDSCC) showing marked nuclear pleomorphism (H and E, ×40). (7) Poorly differentiated carcinoma showing (PDSCC) showing moderate expression of COX-2 with moderate expression in 76%–100% cells (Immunohistochemical score 2 × 4 = 8). (8) Poorly differentiated squamous cell carcinoma (PDSCC) showing negative expression of COX-2 with no staining of tumor cells (Immunohistochemical score 0) (IHC, ×40). (9) Adenocarcinoma showing glands (H and E, ×40) and nuclear pleomorphism (H and E, ×40). (10) Adenocarcinoma showing strong expression of COX-2 with tumor cells showing strong intensity of staining in 76%–100% cells (Immunohistochemical score 3 × 4 = 12) (IHC, ×200). Row 3 (left to right): (11) Adenocarcinoma showing a negative expression of COX-2 with tumor cells showing mild intensity in 51%–75% cells (Immunohistochemical score 1 × 3 = 3) (IHC, ×200). (12) Clear cell carcinoma having clear cytoplasm and abundance of eosinophils (H and E, ×100) (13) Adenosquamous carcinoma with well-defined squamous component (H and E, ×40). (14) Adenosquamous carcinoma showing strong expression of COX-2 with strong intensity of staining in 50%–75% cells (3 × 3 = 9) (IHC, ×40). (15) Moderately differentiated carcinoma (H and E, ×40)

Figure 1: Row 1 (left to right): (1) Moderately differentiated squamous cell carcinoma showing keratinization and intercellular bridges (H and E, ×40). (2) Well differentiated squamous cell carcinoma showing keratinization and intercellular bridges (H and E, ×40). (3) Moderately differentiated squamous cell carcinoma (MDSCC) showing strong expression of COX-2 with strong intensity in 50%–75% cells (Immunohistochemical score 3 × 3 = 9) (IHC, ×40). (4) Moderately differentiated squamous cell carcinoma (MDSCC) showing strong expression of COX-2 with strong intensity in 50%–75% cells (Immunohistochemical score 3 × 3 = 9) (IHC, ×40). (5) Well-differentiated squamous cell carcinoma showing strong expression COX-2 staining (Immunohistochemical score 3 × 4 = 12) (IHC, ×40). Row 2 (left to right): (6) Poorly differentiated squamous cell carcinoma (PDSCC) showing marked nuclear pleomorphism (H and E, ×40). (7) Poorly differentiated carcinoma showing (PDSCC) showing moderate expression of COX-2 with moderate expression in 76%–100% cells (Immunohistochemical score 2 × 4 = 8). (8) Poorly differentiated squamous cell carcinoma (PDSCC) showing negative expression of COX-2 with no staining of tumor cells (Immunohistochemical score 0) (IHC, ×40). (9) Adenocarcinoma showing glands (H and E, ×40) and nuclear pleomorphism (H and E, ×40). (10) Adenocarcinoma showing strong expression of COX-2 with tumor cells showing strong intensity of staining in 76%–100% cells (Immunohistochemical score 3 × 4 = 12) (IHC, ×200). Row 3 (left to right): (11) Adenocarcinoma showing a negative expression of COX-2 with tumor cells showing mild intensity in 51%–75% cells (Immunohistochemical score 1 × 3 = 3) (IHC, ×200). (12) Clear cell carcinoma having clear cytoplasm and abundance of eosinophils (H and E, ×100) (13) Adenosquamous carcinoma with well-defined squamous component (H and E, ×40). (14) Adenosquamous carcinoma showing strong expression of COX-2 with strong intensity of staining in 50%–75% cells (3 × 3 = 9) (IHC, ×40). (15) Moderately differentiated carcinoma (H and E, ×40)