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  Indian J Med Microbiol
 

Figure 1: The role of fatty acids in metastasis and growth of cancer cells in the bone marrow niche. Alpha-linolenic acid secreted by adipocytes leads to chronic myeloid leukemia cell line proliferation and survival through the inhibition of PI3K pathway and reduces Bcl-2, while stearic acid increases the expression of Bcl-2 and subsequent tumor cell growth and proliferation. TNF-α: Tumor necrosis factor-alpha, IL-1: Interleukin 1, IL-6: Interleukin 6, CXCL12: Chemokine (C-X-C) ligand 12, CCL2: (C-C motif) ligand 2, ChK1: Checkpoint kinase 1, Bcl-2: B-cell lymphoma 2, PIM2: Proviral integrations of Moloney virus 2, PI3K: Phosphatidylinositol-4,5-bisphosphate 3-kinase

Figure 1: The role of fatty acids in metastasis and growth of cancer cells in the bone marrow niche. Alpha-linolenic acid secreted by adipocytes leads to chronic myeloid leukemia cell line proliferation and survival through the inhibition of PI3K pathway and reduces Bcl-2, while stearic acid increases the expression of Bcl-2 and subsequent tumor cell growth and proliferation. TNF-α: Tumor necrosis factor-alpha, IL-1: Interleukin 1, IL-6: Interleukin 6, CXCL12: Chemokine (C-X-C) ligand 12, CCL2: (C-C motif) ligand 2, ChK1: Checkpoint kinase 1, Bcl-2: B-cell lymphoma 2, PIM2: Proviral integrations of Moloney virus 2, PI3K: Phosphatidylinositol-4,5-bisphosphate 3-kinase