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An official publication of the Middle-Eastern Association for Cancer Research
Clinical Cancer Investigation Journal
ISSN Print: 2278-1668, Online: 2278-0513
ARTICLE
Year: 2018   |   Volume: 7   |   Issue: 4   |   Page: 132-136     View issue

Increased visceral adipose tissue in male patients with clear cell renal cell carcinoma


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Abstract

Background: Excessive accumulation of adipose tissue, mainly visceral, can determine adipocyte- and adipose tissue-related disorder. Visceral adipocytes secrete mediators associated with carcinogenesis. Several studies have shown a correlation between blood levels of these mediators and clear cell renal cell carcinoma (ccRCC). Indeed, specific biomarkers, including adipokines, have been considered as a possible link between obesity and RCC. Objective: The objective of the study is to test the hypothesis that there is an increase of visceral adipose tissue (VAT) in male patients with ccRCC. Methods: In this retrospective study, two groups were included: A group of patients with ccRCC and a control group without a history of malignancies. Total adipose tissue (TAT) area, VAT area, and subcutaneous adipose tissue (SAT) area were measured in both groups. VAT/SAT ratio was subsequently calculated. Results: Statistically significant differences between the two groups were found in VAT area (P = 0.01) and VAT/SAT ratio (P < 0.05), while no significant difference was found in TAT area and SAT area. Conclusions: This study shows an increased VAT in male patients with ccRCC.

Cite this article
Vancouver
Greco F, Cirimele V, Mallio C, Zobel B, Grasso R. Increased visceral adipose tissue in male patients with clear cell renal cell carcinoma. Clin Cancer Investig J. 2018;7(4):132-6. https://doi.org/10.4103/ccij.ccij_62_18
APA
Greco, F., Cirimele, V., Mallio, C., Zobel, B., & Grasso, R. (2018). Increased visceral adipose tissue in male patients with clear cell renal cell carcinoma. Clinical Cancer Investigation Journal, 7(4), 132-136. https://doi.org/10.4103/ccij.ccij_62_18

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ISSN Print: 2278-1668, Online: 2278-0513