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Squamous cell carcinoma is a common histological type for laryngeal cancer and primary laryngeal small cell carcinoma (LSCC) is a rare occurrence. The prognosis of LSCC is also considered to be poor. We present here a case of 40-year-old female with localized primary small cell carcinoma of the larynx. The diagnosis of LSCC was made after histopathological examination and confirmed by immunohistochemistry study. The patient was treated by concurrent radiotherapy and chemotherapy. In our limited experience, there was a good therapeutic response to treatment of localized primary small cell carcinoma of the larynx.
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