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  Citation statistics : Table of Contents
   2017| November-December  | Volume 6 | Issue 6  
    Online since January 4, 2018

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Neutrophilic eccrine hidradenitis in a patient of acute myeloid leukemia on chemotherapy with cytarabine
Priyanka S Ghuge, Rusina S Karia, Ram H Malkani
November-December 2017, 6(6):261-263
Neutrophilic eccrine hidradenitis (NEH) is a dermatosis affecting the eccrine glands in particular characterized by acute, self-limited, inflammatory papules and plaques and has been commonly described in patients with cancer – particularly acute myeloid leukemia (AML) – who are on chemotherapy. We present the case of a febrile neutropenic patient receiving chemotherapy for AML and presented with well-defined erythematous macules and papule suggestive of NEH. This report emphasizes the necessity of a prompt diagnosis in order to prevent the use of multiple antibiotics and inadvertent use of other drugs as it is a self-limiting condition.
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Cytological diagnosis of enchondroma: Report of three cases
Manoj Kumar Patro, Tummidi Santosh, Atanu Kumar Bal, Bandana Mishra
November-December 2017, 6(6):258-260
Enchondroma is a benign hyaline cartilage neoplasm arising in the medullary region of the bone. Most commonly involves short tubular bones. Most of the lesions are asymptomatic slow-growing lesions detected accidentally on the radiological examination or presents with pain secondary to pathological fracture. Fine-needle aspiration (FNA) is a quick, less invasive procedure and is of help in diagnosing these lesions. We report three cases of enchondroma, two involving phalanges of hand, one in humerus diagnosed by FNA and confirmed by histopathological study. The triad of clinical, radiological and cytological evaluation is imperative for the cytodiagnosis of this well-established entity.
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‘Bronchoscopic Characterization of Lesions’: Significant impact on lung cancer diagnosis with use of Transbronchial needle aspiration (TBNA) in Comparison to conventional diagnostic techniques (CDTs)
Shital Patil, Ayachit Rujuta
November-December 2017, 6(6):239-246
Background: Lung Cancer is the leading cause of cancer deaths around the world. Lung cancer accounts for 13.8% of all cancer diagnosis in India. Aims: (1) To find the role of bronchoscopic characterization of lesions and its impact on outcome in yield in lung cancer with use of conventional diagnostic techniques. (2) To observe additional yield of transbronchial needle aspiration (TBNA) in comparison to other conventional diagnostic techniques (CDTs) such as bronchial wash (BW), bronchial brush (BB), and forcep biopsy. Settings and Design: This is a prospective muticentric study conducted during June 2013–December 2016 at bronchoscopy unit of Venkatesh Chest Hospital Latur and Pulmonary Medicine, MIMSR Medical College Latur India. Materials and Methods: The study included 210 patients on the basis of clinical and radiological features of malignancy after inclusion and exclusion criteria and institutional review board approval. Fiberoptic bronchoscopic abnormalities were categorized as Exophytic endobronchial lesions, submucosal lesions, peribronchial lesions, and no abnormality. TBNA and other CDTs such as forcep biopsy, BB, and BW were performed during bronchoscopy procedure. Histopathological and cytological examinations of specimens were performed at pathology department. Statistical Analysis Used: The statistical analysis was done using Chi-square test. Results: In exophytic endobronchial lesions, yield of TBNA, CDTs, and TBNA plus CDTs was 62.60%, 79.67%, and 84.55%, respectively (P < 0.001). TBNA was found complementary to CDTs. TBNA has an additive yield in aiding diagnosis by 4.87%. In submucosal lesions, TBNA has low yield, i.e., 38.88% as compared to forcep biopsy, i.e., 47.22% in diagnosing lung malignancies. The additional diagnostic yield of other CDTs such as BB and BW has nil effect on yield difference over forcep biopsy (P > 0.8). In peribronchial lesions, TBNA has significant yield, i.e., 63.41% individually as compared to forcep biopsy 26.82% and CDT 39.02% (P < 0.001). Overall diagnostic yield of fiberoptic bronchoscopy in confirming the diagnosis was 71.95%. Conclusions: Bronchoscopic characterization of lesions and use of technique accordingly during bronchoscopy has a significant outcome in the form of yield also it will decrease the need for repeat bronchoscopy.
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The association of human papillomavirus infection in indian cohort of head-and-neck squamous cell cancer patients and its impact on treatment outcome
Satyaveer Singh, Vipul Nautiyal, Neena Chauhan, Meenu Gupta, Mushtaq Ahmad
November-December 2017, 6(6):247-253
Context: Head and Neck Squamous Cell Carcinomas (HNSCCs) patients with HPV-infected tumors have more favorable prognosis, however data is very sparse in Indian literature. Aim: Our study aims to detect p16 (a surrogate for tumor HPV DNA) in HNSCC and its effect on the survival of the patients. Settings and Design: Observational (prospective study). Materials and Methods: This study was conducted amongst 50 cases of HNSCC. All tissue samples for biopsy were subjected to Immunohistochemistry to study p16 expression, a surrogate marker for HPV. The patients were treated by Radiotherapy or concurrent chemo-radiotherapy depending on performance status and stage of disease. Evaluation was done at 3, 6, 12, 18, and 24 months after treatment. Survival analysis was used to check the outcome of Radiotherapy using Kaplan Meyer survival curves and cox proportional hazards model. Results: Majority of patients had Stage III disease (33 patients – 66%). 16 (32%) patients were HPV positive and 34(64%) were negative. Out of the 16 HPV positive cases, majority, 15 (93.75%) cases were associated with oropharyngeal carcinoma. 2 year DFS for HPV positive was 84% compared to 58% in HPV negative patients (P = 0.089) and 2 year overall survival for HPV positive patients was 83% compared to 52% for HPV negative patients (P = 0.03). Conclusions: Our study concluded that 32% of the HNSCC patients were positive for HPV. Patients who were HPV positive had better disease free survival and overall survival.
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Study to correlate the histopathological spectrum of bone lesions with demographic profile of patients in a tertiary care institution
Kunjal Mukesh Karia, M Banyameen Iqbal, Amardeep Ajinath Patil, Neekita Shriram Agrawal, Harsh Kumar
November-December 2017, 6(6):254-257
Background: Bone lesions are less commonly encountered lesions, and they pose a definite diagnostic challenge. Aims and Objective: The aims and objective of this study is to determine and correlate various bone lesions histopathologically with age and gender. Materials and Methods: A combined retrospective and prospective study of all bone lesions was done for 2 years from May 2015 to April 2017 in the histopathology section of the department of pathology at a tertiary care teaching hospital. A total of 148 cases of different bone lesions were studied. Relevant history, clinical data, and radiological reports were obtained from the requisition forms submitted. Results: The present study shows that the incidence of nonneoplastic bone lesions is 59.46% and that of benign neoplastic lesions is 29.73%. The malignant bone lesions accounted for 10.81%. The younger males were commonly affected (60.81%). The peak age incidence of bony lesions was found to be 21–30 years in 21.62% of the cases. The inflammatory lesions (36%) were commonly encountered nonneoplastic lesions. Among the neoplastic lesions, giant cell tumor (40.90%) and metastatic bony deposits (43.75%) were the most common benign and malignant tumors, respectively. Conclusion: Inflammatory lesions were the most common nonneoplastic lesion. Among the neoplastic bony lesions, giant cell tumor is the most common benign tumor, and metastatic deposits were the common malignant lesions. The clinical data, radiology, and histopathology all when correlated help to establish the correct diagnosis of bone lesions.
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Wilms' tumor gene 1 in leukemia: Prognostic or predictive biomarker
Saeid Shahrabi, Behrouz Yazdanpanah, Kaveh Jaseb, Mohammad Shahjahani, Elahe Khodadi
November-December 2017, 6(6):233-238
Wilms' tumor is common in children and is caused by Wilms' tumor gene 1 (WT1). The WT1 mutation has been reported in a variety of hematologic malignancies. Changing expression of miRNA molecules has also been shown to play a role in the development of Wilms' tumor. Considering the fact that WT1 can be used as a clinical biomarker in leukemia cases, it can be a basis for immunotherapy of leukemia. WT1 is a gene that can be used as a prognostic biomarker for minimal residual disease, as well as the detection of relapse for clinical remission in leukemia. Furthermore, it can be considered as a predictive biomarker for the treatment of leukemic patients after allogeneic transplantation. This study aimed to review WT1 expression in leukemia, its involvement in miRNAs expression, as well as its importance in prognosis and treatment of leukemia.
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