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   2012| January-March  | Volume 1 | Issue 1  
    Online since April 13, 2012

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Long term survival in paratesticular rhabdomyosarcoma
Ritesh Kumar, Shreekant Bharti, Divya Khosla, Rakesh Kapoor
January-March 2012, 1(1):31-32
Paratesticular rhabdomyosarcoma (RMS) is a rare tumor arising from the mesenchymal tissues of the spermatic cord, epididymis, testis and testicular tunics. It represents only 7% of all patients entered in the Intergroup Rhabdomyosarcoma Study (IRS) and 17% of all malignant intrascrotal tumors in children less than 15 years old. We report a case of a 13-year-old male with left paratesticular RMS who was treated successfully with surgery and systemic chemotherapy. The patient is disease-free after 7 years of treatment completion.
  5,498 185 -
Sex hormones in head and neck cancer: Current knowledge and perspectives
Harkanwal Preet Singh, Prince Kumar, Roshni Goel, Ashish Kumar
January-March 2012, 1(1):2-5
Head and neck cancer (HNC) is an increasing problem worldwide. Oral carcinogenesis is a highly complex multifocal process. Molecular mechanisms contributing to initiation and progression of head and neck squamous cell carcinoma are still poorly known. Endocrine microenvironment is another imperative factor beside other well-documented risk factors like tobacco smoking, alcohol and infections in causing cancers of head and neck. These endocrine hormones play a role in tumor progression in case of cancers characteristically expressing sex hormone receptors, and it has been proven that these receptors also reside outside the sex organs in the larynx and lungs. However, the role of sex hormones in HNC is controversial, and few studies have been conducted to delineate their role in HNC. So, this review article is an attempt to draw an attention towards the potential role of sex hormones in pathogenesis of HNC and potential therapeutic modalities to prevent onset and progression of cancer.
  4,270 413 3
Nanogoldtechnology-imaging, sensing and target therapy in head and neck cancer
Nishat Sultana, Suraksha Bhat Shenoy, ME Sham, Shilpa Keshav, Rachna Kaul
January-March 2012, 1(1):6-12
Innovation in the last decade has endowed nanotechnology with an assortment of tools for delivery, imaging, and sensing in cancer research. Cancer nanotherapeutics are rapidly progressing and are being implemented to solve several limitations of conventional drug delivery systems such as nonspecific biodistribution and targeting, lack of water solubility, poor oral bioavailability, and low therapeutic indices. To improve the biodistribution of cancer drugs, nanoparticles have been designed for optimal size and surface characteristics to increase their circulation time in the bloodstream. Nanoparticles have the ability to accumulate in cells without being recognized by P-glycoprotein, one of themainmediators of multidrug resistance, resulting in the increased intracellular concentration of drugs. Multifunctional and multiplex nanoparticles are now being actively investigated and are on the horizon as the next generation of nanoparticles, facilitating personalized and tailored cancer treatment.
  4,027 338 1
"Pure" invasive apocrine carcinoma of the breast with psammoma bodies
Kavita Mardi, Shivani Sharma
January-March 2012, 1(1):37-39
Pure apocrine carcinomas are rare, morphologically distinct type of invasive of breast carcinomas, and represent about 0.5% of all invasive breast cancers. Existence of psammoma bodies (PBs) is extremely rare. Cytological, histological and immunohistochemical features of a case of apocrine carcinoma of the breast with PBs is described in a 56-year-old female. This report emphasizes the rarity of this lesion and supports currently held beliefs about the formation of PBs.
  4,118 190 -
High-risk human papillomavirus infections in colorectal cancer in the Syrian population and their association with Fascin, Id-1 and P-cadherin expressions: A tissue microarray study
Lina Ghabreau, Eric D Segal, Amber Yasmeen, Amal Kassab, Nizar Akil, Ala-Eddin Al Moustafa
January-March 2012, 1(1):26-30
Background: High-risk human papillomaviruses (HPVs) can be regarded as important risk factors for colorectal carcinogenesis and metastasis. Alternatively, earlier studies have reported that Fascin, Id-1 and P-cadherin genes are important regulators of cell invasion and metastasis in several human carcinomas, including colorectal. In order to investigate the correlation between the presence of high-risk HPVs and Fascin, Id-1, and P-cadherin genes in human colorectal cancer (CRC) in the Syrian population, we examined the incidence of high-risk HPV types (16, 18, 31, 33 and 35) and their association with Fascin, Id-1 and P-cadherin expression. Materials and Methods: A total of 78 blocks from CRC Syrian patients were used in this study. These blocks were analyzed using polymerase chain reaction (PCR) and tissue microarray (TMA) analyses for the presence of high-risk HPVs and Fascin, Id-1 as well as P-cadherin expression, respectively. Results: We found that high-risk HPVs were present in 42 samples (53.84%), which represent the majority of invasive CRC cases; the most frequent high-risk HPV types in the Syrian population are 16, 33, 18, 35 and 31 respectively. Furthermore, the expression of E6 onco-protein of high-risk HPVs was found to be correlated with Fascin, Id-1 and P-cadherin expression/over-expression in the majority of CRC tissue samples. Conclusion : These data reveal that high-risk HPVs are present in human CRCs in the Syrian population, and their presence is associated with invasive and metastatic phenotype.
  3,191 184 8
High ezrin immunoreactivity is an indicator of poor survival in squamous cell carcinoma of uterine cervix
Tahany Mohamed Shams, Hanaa Omar Badr-El-Din, Iman Loay Hussein Abulkheir
January-March 2012, 1(1):16-22
Context: Ezrin, the membrane-linking protein, is highly expressed in several types of human cancers, and correlations between its immunoreactivity and histopathological data as well as patient outcome have previously been shown. Aims: The aim of our study was to investigate the expression of ezrin in cases of cervical squamous cell carcinoma, then correlate the data with survival and other clinicopathological variables. Materials and Methods: We carried out immunohistochemical analysis of ezrin in 64 cases of cervical cancer and correlated it to clinicopathologic variables and disease outcome. Results: Ezrin was identified in 50 (78.1%) of 64 studied cervical cancer cases, which was classified as weak, moderate and marked in 16%, 28% and 56%, respectively. In contrast to the predominantly membranous immunoreactivity in normal cervical epithelium, it was cytoplasmic in cancer cells. Ezrin expression significantly correlated with lymph node metastasis and development of distant metastasis (P<0.001 and 0.0006, respectively), as well as with tumor grade and stage (P=0.02 and 0.05, respectively), but not with other variables such as age, tumor size, and histological type. Regarding outcome, high ezrin expression was associated with short disease-specific survival (DSS) and disease-free survival (DFS) and poor metastasis survival (MS); (P<0.001). Ezrin expression significantly predicted both the 5-year MS, DSS, and DFS, recording P value<0.001 in each. Conclusions: Our results suggested that ezrin expression may represent an effective prognostic marker and a potential target for treatment of invasion and metastasis in cervical cancer.
  2,600 204 -
Verrucous carcinoma over the penis presenting as nail-like cutaneous horn
Varadraj V Pai, Naveen N Kikkeri, Tukaram Sori, Udupi D Shastri
January-March 2012, 1(1):33-34
Cutaneous horn over the penis presents as a rare conical, hyperkeratotic nodule. About one-third of the cases are associated with malignancy. Herein, we report a case of verrucous carcinoma over the penis, presenting as a nail.
  2,362 135 1
Cholinesterase in osteosarcoma
Simmi Kharb, Zile Singh Kundu, Sandeep Kumar
January-March 2012, 1(1):13-15
Background: Several biochemical markers have been proposed to have diagnostic and prognostic value in the management of osteosarcoma. Cholinesterase affects cell proliferation, differentiation and responses to various insults, including stress, and might have functional role in bone tissues. Status of serum cholinesterase levels in osteosarcoma is not clear. Hence, the present study was planned to analyze the status of cholinesterase in patients with osteosarcoma. Methods: Serum cholinesterase levels were analyzed in 30 cases of osteosarcoma and 30 patients with musculoskeletal pain. Results: Serum calcium and alkaline phosphatase levels were significantly raised with osteosarcoma (group I) as compared with controls (group II) (P<0.01). Serum phosphorus levels were lower in group I as compared with group II and the difference was not statistically significant (P>0.05). Serum cholinesterase levels were decreased in osteosarcoma patients (group I) as compared with the patients with musculoskeletal pain (group II, P<0.05). Conclusion: Findings of low levels of serum cholinesterase levels in the present study demonstrate that cholinesterase secreted by osteoblasts is consumed in bone formation and tumorigenesis.
  2,162 192 -
Helicobacter pylori in colorectal neoplasms of Kashmiri patients: What is the prevalence?
Aga Syed Sameer, Safiya Abdullah, Saniya Nissar, Roohi Rasool, Shahid Mudassir Baba, Mushtaq A Siddiqi
January-March 2012, 1(1):23-25
Background: The purpose of the present study was to detect the presence of Helicobacter pylori in colorectal cancer (CRC) patients in Kashmiri population. Materials and Methods: A total of 86 CRC samples were studied. Samples were taken from tissues suitable for DNA amplification by polymerase chain reaction (PCR). DNA was extracted and H. pylori detection was carried out by PCR amplification of glmM gene. Results: Out of 86 samples, only eight were H. pylori-positive for amplification glmM gene of a 294 bp DNA fragment. Conclusion: H. pylori is not the prominent risk factor for the development of colorectal cancer in Kashmiri population.
  2,168 164 1
Paraganglioma of cauda equina
Prashant B Mahalingashetti, Sunil Kumar Bylappa, Akkem V Jyothi, Ramaswamy A Subramanian
January-March 2012, 1(1):35-36
Spinal paragangliomas are rare benign tumors. Preoperative diagnosis is difficult, as they share common clinical and radiological features with other lesions at this site. We report an unusual case of paraganglioma in the cauda equina region in a 60-year-female. Ventricular ectopics were noted intraoperatively during surgical removal. Characteristic histology led to definitive diagnosis.
  2,061 147 -
Middle-Eastern association for cancer research and its activities dreams come true
Ala-Eddin Al Moustafa
January-March 2012, 1(1):1-1
  1,566 179 -