Clinical Cancer Investigation Journal

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 5  |  Issue : 5  |  Page : 374--383

Profile of molecular subtypes of breast cancer with special reference to triple negative: A study from Northeast India


Gayatri Gogoi, Mondita Borgohain, Projnan Saikia, Syed Abul Fazal 
 Department of Pathology, Assam Medical College, Dibrugarh, Assam, India

Correspondence Address:
Gayatri Gogoi
Assam Medical College, Dibrugarh - 786 002, Assam
India

Background: Different molecular classes of breast cancer (BRCA) correlate with prognosis and response to therapy. Triple-negative breast cancer (TNBC) is a newer concept and very limited studies were carried out in India. The aim of this study was to profile the molecular types with a particular emphasis on TNBCs. Materials and Methods: Prospectively evaluated descriptive study for 2 years from June 2014 to March 2016, was carried out in the Department of Pathology and Surgery in a tertiary care institute. Cases included were of invasive breast carcinoma in females, confirmed by histopathology. Ethical clearance was received. Data were analyzed using Statistical SAS software. Results: A total of 123 cases of invasive BRCA were studied and mean age was 44.64 years. The peak age group was 36–45 years (43.9%). Tumor sizes ≥2 cm was 30%, between 2 and 5 cm was 50.40%, over 5 cm was 19.51%. Invasive duct carcinoma was 82.11% and invasive lobular carcinoma 8.13%. Only 21% of subjects presented as early breast carcinoma. Cases of 1–3 nodes were 22.8%, 4–5 nodes 21.1%, more than five nodes were 34%. Histologic Grade 3 was 50.4%, Grade 2 was 41%, and Grade 1 was only 8.1. The American Joint Committee on Cancer, Stage 1 (17.9%) in Stage 2 (29.3%) Stage 3 was 46.3%, Stage 4 was 6.5%. Estrogen receptor was in 40.62%, progesterone receptor 35.77%, Her2/Neu 18.69% luminal A (19.51%), luminal B (21.13%), Her2/Neu type (17.88%), and triple negatives (38.21). Conclusion: The present study showed significantly higher TNBC with poor prognostic factors in younger women in a background of peculiar ethic spectrum in this geographical region.


How to cite this article:
Gogoi G, Borgohain M, Saikia P, Fazal SA. Profile of molecular subtypes of breast cancer with special reference to triple negative: A study from Northeast India.Clin Cancer Investig J 2016;5:374-383


How to cite this URL:
Gogoi G, Borgohain M, Saikia P, Fazal SA. Profile of molecular subtypes of breast cancer with special reference to triple negative: A study from Northeast India. Clin Cancer Investig J [serial online] 2016 [cited 2020 Jul 12 ];5:374-383
Available from: http://www.ccij-online.org/article.asp?issn=2278-0513;year=2016;volume=5;issue=5;spage=374;epage=383;aulast=Gogoi;type=0