Clinical Cancer Investigation Journal

CASE REPORT
Year
: 2012  |  Volume : 1  |  Issue : 3  |  Page : 167--169

Synchronous multicentric pleomorphic xanthoastrocytoma with anaplastic features


Kavita Mardi1, RC Thakur2 
1 Department of Pathology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India
2 Department of Neurosurgery, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India

Correspondence Address:
Kavita Mardi
Associate Professor, 12-A, Type V Quarters, IAS Colony, Kasumpti, Shimla, Himachal Pradesh
India

Pleomorphic xanthoastrocytoma (PXA) has been considered an astrocytic tumor with a relatively favorable prognosis. However, PXA cases having several recurrent patterns with poor prognosis have been reported in recent years, and a new concept of DQPXA with anaplastic featuresDQ has been proposed. The present case was of a 55-year-old male who presented with weakness and numbness of right upper and lower limbs since 3 months along with difficulty in walking as well as difficulty in speaking since then. He also complained of headache since 9 months. The magnetic resonance imaging study revealed two nodular, homogeneously enhancing lesions, approximately 1 cm in size in the right cerebral hemisphere. Clinical and radiological examinations were suggestive of a metastatic neoplasm. A right frontal craniotomy was performed for excisional biopsy of both lesions. Histopathological findings showed that the tumor was PXA with strong pleomorphism, xanthomatous changes, extensive areas of tumor necrosis, and increased mitotic activity. From these findings, the histopathological diagnosis DQPXA with anaplastic featuresDQ was given. Synchronous multicentric PXA presents unique challenges in that gross total resection would impose significant surgical morbidity; histological homogeneity among the lesions cannot be confirmed; and the well-described potential for anaplastic transformation may be increased with multiple lesions. The optimal treatment for patients with this rare and challenging diagnosis awaits further study.


How to cite this article:
Mardi K, Thakur R C. Synchronous multicentric pleomorphic xanthoastrocytoma with anaplastic features.Clin Cancer Investig J 2012;1:167-169


How to cite this URL:
Mardi K, Thakur R C. Synchronous multicentric pleomorphic xanthoastrocytoma with anaplastic features. Clin Cancer Investig J [serial online] 2012 [cited 2020 May 30 ];1:167-169
Available from: http://www.ccij-online.org/article.asp?issn=2278-0513;year=2012;volume=1;issue=3;spage=167;epage=169;aulast=Mardi;type=0