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   Table of Contents - Current issue
Coverpage
January-February 2019
Volume 8 | Issue 1
Page Nos. 1-39

Online since Thursday, April 4, 2019

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ORIGINAL ARTICLES  

Expression of maspin in HBV-related hepatocellular carcinoma p. 1
Bita Moudi, Hamidreza Mahmoudzadeh-Sagheb, Zahra Heidari
DOI:10.4103/ccij.ccij_110_18  
Background: Liver diseases such as HBV-related hepatocellular carcinoma (HCC) are still among the most important health problems in the worldwide. To make successful treatment, an accurate diagnosis is necessary. In the forthcoming study, the level of Maspin protein expression and its relationship with early diagnosis of HBV-related HCC were studied in the liver tissue of Iranian patients. Methods: The study consisted of 30 healthy individuals and 121 patients (HBV, HCC, HBV + HCC). The level of Maspin expression in the liver samples of all volunteers was evaluated by IHC and quantitative real-time reverse transcriptase. Results: Statistically, the level of Maspin expression was different between HBV-related HCC and HBV groups. There was a significant relationship between labeling index and immunohistochemical and molecular expressions of Maspin. The results showed the most appropriate sensitivity and specificity for the diagnosis of patients with HCC (81.0% and 98.9%, respectively). Conclusion: Results emphasized the significant relationship between Maspin expression and risk of HCC in patients with HBV. It was concluded that Maspin expressions could increase significantly in HBV-related HCC patients.
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Is there correlation between CD19, CD20, and CD25 expressions with platelet changes within 6 months in children with immune thrombocytopenic purpura? p. 7
Ali Amin Asnafi, Mostafa Moghtadaei, Masumeh Maleki Behzad, Najmaldin Saki
DOI:10.4103/ccij.ccij_105_18  
Background: Immune thrombocytopenic purpura (ITP) is a bleeding disorder in which the defects of immune system cells play a vital role. The aim of this study was to explore the possible correlation between independent CD markers' expressions and platelet counts in children with ITP. Materials and Methods: The frequency of CD19, CD20, and CD25 markers in the peripheral blood of twenty children with ITP was investigated by flow cytometry, and the possible correlation between the expressions of these markers with platelet counts was analyzed. Results: A significant negative correlation was found between CD20 expression with platelet counts before (P = 0.024) and 10 days after treatment (P = 0.016). There was no significant correlation between the expressions of CD19 and CD25 with platelet counts at different times of follow-up. Moreover, CD20 expression was higher in patients with no response compared to those having complete response to first-line therapies. Conclusion: We found that the expressions of these markers could not be considered as a prognostic factor independent of other contributors involved in ITP pathogenesis. It is important that future studies should focus on the potential effects of other factors involved in ITP pathogenesis and their impact on response to therapy, as well as evaluating CD markers during ITP progression.
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Cancer incidence and mortality pattern in Eastern Mediterranean Regional Office Countries and its association with the human development index p. 15
Saeid Sabzalizadeh-Ardabili, Reza Alizadeh-Navaei, Akbar Hedaytizadeh-Omran, Ghasem Janbabaei
DOI:10.4103/ccij.ccij_90_18  
Purpose: Cancer is one of the main causes of death in the Eastern Mediterranean Regional Office (EMRO) region. The aim of this study was to determine the correlation between cancer incidence and mortality with the Human Development Index (HDI) in the EMRO region. Materials and Methods: The incidence and mortality rates of all cancers were obtained from the GLOBOCAN cancer project, and the data about the HDI were obtained from the United Nations Development Program database. The correlation between incidence, mortality rates, and the HDI parameters was analyzed by SPSS software. Results: The highest age-standardized incidence and mortality rates of cancers in the EMRO region were shown for colorectal cancer (10.19 ± 5.30) and lung cancer (8.92 ± 4.63), respectively, and the lowest was Kaposi's sarcoma in the incidence (0.20 ± 0.14) and mortality rate (0.10 ± 0.09), respectively. The lowest and highest incidence of all cancers in the region pertained to Yemen (80.40) and Lebanon (197.40), respectively. In addition, the lowest and highest mortality from all cancers were in Saudi Arabia (53.90) and Egypt (103.40), respectively. In examining the components of the HDI, gross national income per capita was related to mortality rate of all cancers (P = 0.02). The HDI was related between the incidence rates of colorectal, gallbladder, kidney, lip and oral cavity, multiple myeloma, esophagus, pancreas, and thyroid cancer and the mortality rates of lip and oral cavity, skin melanoma, multiple myeloma, nasopharynx, esophagus, larynx, and pancreas cancers (P < 0.05). Conclusion: The findings of the present study showed that the incidence and mortality rates of some cancers were related to HDI, and the highest correlation was found between the incidence of kidney cancer and the mortality of pancreatic cancer with HDI.
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Immunohistochemical evaluation of P53 and Ki67 in biopsy samples of gastritis and gastric cancer patients p. 21
Mehran Panahi, Zahra Heidari, Hamidreza Mahmoudzadeh-Sagheb, Mehdi Jahantigh, Nadia Sheibak
DOI:10.4103/ccij.ccij_109_18  
Background: Chronic gastritis (CG) is an inflammatory process that can lead to gastric cancer and Helicobacter Pylori (H. Pylori). In this study, immunohistochemical evaluation of P53 and Ki67 in biopsy samples of CG and gastric carcinoma patients with and without H. Pylori infection was investigated. Methods: From 82 archived paraffin blocks, 42 blocks were selected for CG group and 40 as the gastric cancer group. All CG and gastric cancer cases were subdivided into H. Pylori positive and negative subgroups. Monoclonal antibodies specific for Ki67 and P53 were used for immunohistochemical staining. Results: The results showed that differences of Ki67 and P53 expressions were statistically significant among patients with CG gastritis and gastric cancer (P < 0.05). However, there were not significant differences in Ki67 and P53 expression between H. Pylori-positive and H. Pylori-negative subgroups of gastritis and gastric cancer (P > 0.05). Conclusions: The present study proposed that P53 and Ki67 expressions changed in gastric cancer compared to the CG specimens. It seems that overexpression of these biomarkers probably has important roles in the route of carcinogenesis. Our results suggested that these overexpressions were not associated with H. Pylori infection. Further studies with larger sample size are needed in this field.
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Cytogenetic and molecular assessment of childhood acute lymphoblastic leukemia patients from 2014 to 2017 in Ahvaz p. 28
Arash Alqasi, Yousef Tavakolifar, Hadi Rezaeeyan, Najmaldin Saki, Soheila Bagherpour, Marziyeh Abbasi Nasab
DOI:10.4103/ccij.ccij_103_18  
Background: Acute lymphoblastic leukemia (ALL) is the most common hematological malignancy in children that is caused by gene mutations and chromosomal rearrangements in lymphoid cells. Aim: In this study, for the first time, the prevalence of cytogenetic and molecular genetic abnormalities was discussed in children with ALL from 2014 to 2017 in Ahvaz. Materials and Methods: A total of 72 children were diagnosed as ALL patients by morphology, clinical examinations, and flow cytometry assays. Cytogenetic and molecular genetic analysis was done on bone marrow (BM) samples by BM culture and reverse transcription-polymerase chain reaction technique, respectively. Descriptive data analysis was done using SPSS software. Chi-square and independent samples t-test was used to assess the correlation between variables. Results: Sixty-five cases (90.3%) were preB lineage and 7 cases (9.7%) were T-lineage out of 72 ALL patients, t(9,22) BCR-ABL (p190) is the most frequent cytogenetic and molecular genetic abnormality in preB ALL (7%) and T-ALL patients (28.6%), respectively. t(4,3) inv (16) and t(2,8) were introduced as novel cytogenetic abnormalities in preB ALL cells. No significant correlation was found between gender, molecular genetic abnormalities, and white blood cell count in patients. Conclusion: For the first time in this study, the highest percentage of cytogenetic and molecular genetic abnormalities was related to t(9,22) BCR-ABL in both ALL subtypes in children. The evaluation of cytogenetic and molecular genetic abnormalities in children with ALL is essential in estimating the prognosis in both preB and T-ALL subtypes, which will be a great contribution to achieve a better diagnosis and develop appropriate therapeutic approaches.
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CASE REPORTS Top

Cutaneous Ewing's sarcoma of scalp with lung metastases in an elderly female: A rare case report p. 33
Pulkit Nag, Joseph Rajiv Thipparampalli, Puneet Pareek
DOI:10.4103/ccij.ccij_111_18  
Ewing's sarcoma (ES) is a primitive neuroectodermal tumor. It is usually a primary bone tumor but rarely occurs in the skin and subcutaneous tissues (primary cutaneous ES [PCES]). It usually involves the deep subcutaneous tissue or muscles and rarely occurs as primary skin cancer. Most patients are white, women, and in the second decade of life. The diagnosis is made by aspiration cytology, histochemical stains, immunohistochemistry, electron microscopy, cytogenetics, and molecular genetics of translocations. Due to their rarity and morphological similarity to other cutaneous tumors, ESs are subject to being clinically and pathologically underdiagnosed. Cutaneous ES has a better prognosis than primary bone or soft-tissue ES, with a survival rate of 91% in 10 years and the presence of metastasis being rare. At present, no specific treatment guidelines inform the management of cutaneous Ewing tumor. The treatment modalities are extrapolated based on the management of bone ES while includes neoadjuvant chemotherapy, surgery, adjuvant chemotherapy (±radiotherapy), and autologous bone marrow transplantation in high-risk patients. Standard first-line treatment for patients with these tumors includes chemotherapy with a five-drug regimen of vincristine, doxorubicin (Adriamycin®), and cyclophosphamide, alternating with ifosfamide and etoposide. We report a rare case in a 60-year-old female diagnosed as PCES with lung metastases, treated by palliative chemotherapy.
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Inflammatory pseudotumor of urinary bladder: A masquerader of bladder malignancy p. 36
Aanchal Bhayana, Ritu Nair Misra, Sunil Kumar Bajaj, Rajni Prasad
DOI:10.4103/ccij.ccij_104_18  
Inflammatory pseudotumor of urinary bladder is a rare benign disease of unknown etiology, characterized by nonneoplastic proliferation of fibroblastic spindle cells, in a background of myxoid and granulation tissue. We report a case of an inflammatory pseudotumor of urinary bladder and discuss the important differentials. A 47-year-old woman presented with longstanding frequency and urgency of micturition. Ultrasound pelvis, color Doppler, computed tomography, and magnetic resonance imaging were performed. Focal bladder wall thickening at the dome was observed. In addition, there was a heterogeneous solid cystic intramural lesion within this bladder wall thickening showing peripheral rim enhancement with nonenhancing central component. Repeated urine cultures were sterile and urine cytology was found to be negative for malignancy. Finally, histopathology and immunohistochemistry confirmed this lesion to be inflammatory pseudotumor.
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