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ORIGINAL ARTICLE
Year : 2020  |  Volume : 9  |  Issue : 4  |  Page : 114-120

Meningioma and expression of human leukocyte antigen-B5, 7, 8, 27, and 51: Is there any relevance?


1 Department of Neurosurgery, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
3 Thalassemia and Hemoglobinopathy Research Center, Health Research Institute; Department of Laboratory Sciences, School of Allied Medical Sciences; Department of Laboratory Sciences, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Correspondence Address:
Ali Amiri
Department of Neurosurgery, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ccij.ccij_44_20

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Background: Cerebral meningiomas are among the most prevalent brain tumors. Most cases of cerebral meningioma are benign and respond well to the treatment. However, there is no conclusive laboratory method for screening of such tumors. Given the lack of a screening approach for meningiomas, we examined the expressions of human leukocyte antigen (HLA)-B5, 7, 8, 27, and 51 in patients with cerebral meningioma in this research in order to achieve a reliable laboratory parameter in this regard. Materials and Methods: Patients with cerebral meningioma who referred to Golestan Hospital, namely one of the largest neurosurgery centers in the southwest of Iran, were identified and examined over a 2-year period. After confirmation of cerebral meningioma diagnosis, the patients were enrolled in the study. Results: There was no significant relationship between the expressions of the abovementioned HLAs with platelet parameters, lymphocyte, monocyte, and neutrophil counts, clinical manifestations, family history, drug consumption, and alcohol abuse. A higher expression level of HLA-B5 was observed in the patients. Conclusion: With regard to the expression of HLA-B5 in nearly one-third of patients, it is likely to use this antigen or its serotype, namely HLA-B51, as a laboratory marker for screening of disease in the future through the study of larger populations.


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