|Year : 2019 | Volume
| Issue : 6 | Page : 232-235
Genitourinary tract cancers: Frequency and demographic characteristics
Zahra Tolou_Ghamari1, Hamid Mazdak1, Masih Saboori2, Mehrdad Mohammadi Sichani1
1 Isfahan Kidney Transplantation Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Neurosurgery, Isfahan University of Medical Sciences, Isfahan, Iran
|Date of Web Publication||19-Nov-2019|
Isfahan Kidney Transplantation Research Center, Isfahan University of Medical Sciences, Isfahan
Source of Support: None, Conflict of Interest: None
Context: As one of the most common cancers in clinical practice, genitourinary system tumors are reported to grow worldwide. Aims: We aimed to describe the frequency and demographic characteristics of such cancers' in Isfahan Province/Iran. Materials and Methods: Information related to the genitourinary system tumors was collected from the Isfahan Cancer Registry. The cancer sites studied were defined according to the International Classification of Diseases (ICD-O; Third Edition) and recorded by associating topography code. Statistical Analysis Used: The statistical analyses of d-Base were performed using Microsoft Excel and SPSS v. 20 (Chicago, IL, USA) for windows. Results: Among all registered patients with genitourinary cancers, there were 3024 cases with genital system cancers and 2117 cases with urinary system cancers. The frequency of males versus female genital system cancers was (n = 1808 vs. n = 1216; P = 0.01), respectively. The frequency of bladder and kidney cancer was 1655 and 404 cases, respectively. Conclusions: According to the analysis, there were higher frequency of ovary and prostate cancer in male and females correspondingly. Associated with the urinary system, cancers of bladder and kidney were higher than others. Further advanced study associated with drug therapy and surgical management seems to be advantageous.
Keywords: Cancer, frequency, genital, Isfahan, urinary, genitourinary
|How to cite this article:|
Tolou_Ghamari Z, Mazdak H, Saboori M, Sichani MM. Genitourinary tract cancers: Frequency and demographic characteristics. Clin Cancer Investig J 2019;8:232-5
|How to cite this URL:|
Tolou_Ghamari Z, Mazdak H, Saboori M, Sichani MM. Genitourinary tract cancers: Frequency and demographic characteristics. Clin Cancer Investig J [serial online] 2019 [cited 2020 Jan 28];8:232-5. Available from: http://www.ccij-online.org/text.asp?2019/8/6/232/271317
| Introduction|| |
The organ system of the reproductive organs and the urinary system called genitourinary system or urogenital system. Renal system, urinary tract, or urinary system involved of the kidneys, ureters, bladder, and the urethra. Primary sex organs included as testis in the male and the ovary in the female. The cancers of genitourinary tract are common and include a range of lesions extending from small benign tumors to destructive neoplasms with high mortality. In clinical practice, genitourinary tumors are categorized as one of the most common tumors with a significant morbidity and mortality. The tumors include a broad spectrum associated with age, location, histology, and clinical outcome.
Associated with the urinary system, the malignant transformation could affect any section of the urothelium. More than 90% of urinary system cancers are urothelial carcinoma. Rare cancers comprise squamous cell carcinoma, small cell carcinoma, and adenocarcinoma. Benign neoplasms are also occasionally seen. Rare cancers comprise squamous cell carcinoma, small cell carcinoma, and adenocarcinoma. Benign neoplasms are also occasionally seen. In a recent study performed in Isfahan Province, Iran, a period prevalence of 33.2 was reported for bladder cancer. In an Indian study, in both sexes, genitourinary tumors reported as 20.8% among other cancers.
Regarding to upper tract, urothelium cancers categorized as the vast majority types. Cancers of the ureter and renal pelvis are less common, including only 4% of urothelial malignancy.,
There are reports regarding to worldwide frequency and pattern of female genital malignancy such as cancers of cervix (66.3%), ovarian (21.1%), corpus uteri (9%), and the vulva (3.6%). In a study performed in the Iranian population with high-risk human papillomaviruses (HPVs) cervical cancer, HPV 16 was the most common HPV detected in our population with a very low prevalence of HPV 18. In addition, HPV 6 and then HPV 11 had the most prevalence rate in the women with uterine cervix (cervical) infection among low-risk HPVs. The previous report confirmed that patients with a higher rate of high-risk HPV infection show endometriosis that might develop into cancer.
The benefits of evidence-based strategies in the management of genitourinary tumors have been documented since the 1970s. Therefore, to provide some of the information challenging genitourinary oncology epidemiology research, the purpose of this manuscript was to investigate demographic and the frequency of genitourinary system cancers in Isfahan Province, Iran.
| Materials and Methods|| |
Genitourinary cancer data from the years 2011 to 2015 were obtained from the Isfahan Cancer Registry, located at the Isfahan Deputy of Health. The study was conducted to the Isfahan Kidney Transplantation Research Center. The Isfahan Cancer Programme is intended to be recorded all cancer cases in the Isfahan. The cancer sites studied were defined according to the International Classification of Diseases (ICD-O; Third Edition). Genitourinary cancers were defined by the related topography code (C64–C68 for urinary systems, C60–C63 for male genital, and C51–C58 for female genital). The statistical analyses of d-Base were performed using Microsoft Excel and SPSS for windows.,,,,
The normality distribution test of the patient population was studied in comparisons associated with the age of males and females. In order to examine the differences between age and frequencies with gender, the t-test was used.
| Results|| |
There were 5141 patients with genitourinary system cancers. With a minimum of 2 and a maximum of 110, the mean ± standard deviation (SD) associated with age in the population studied was 63.5 ± 15.8 years old. [Figure 1] shows the frequency of patients with genitourinary tract cancers according to age. The most occurrences of cancers (82%) were at the ages between 50 and 90 years old of patients' life.
|Figure 1: Distribution of age in patients with genitourinary system cancers|
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[Table 1] shows the frequency of genitourinary tract cancers. As shown in [Figure 2], cancers of genital system with a frequency of 3024 were higher than the frequency of urinary system cancers (n = 2117). The frequency of males versus female genital system cancers was (n = 1808 vs. n = 1216; P = 0.01), respectively. In females, the frequency of genital system cancers ranked as: ovary (437), uterine corpus (n = 401) > uterine cervix (n = 237) > uterus (n = 100) > vulva (n = 15) > vagina (n = 11), placenta (n = 1), and unspecified site (n = 14).
In males, the frequency of genital system cancers ranked as: prostate (n = 1648), testis (n = 147), penis (n = 5), and penis and other genital (n = 8).
The frequency of urinary system in both genders ranked as: bladder (n = 1655), kidney (n = 404), renal pelvis (n = 21), ureter (n = 18), and other and unspecified urinary organs (n = 19). The estimated frequency associated with living cases versus dead cases was (n = 2115 vs. n = 809, P = 0.001) for genital system cancers and (n = 1881 vs. n = 236, P = 0.001) for urinary system cancers.
| Discussion|| |
Genitourinary oncology focuses on epidemiology, pharmacotherapy, and clinical research of urinary and genital system cancers' in both genders. In agreement with previous publication that reported a higher incidence of genitourinary system cancers in men than in women, in this study, the frequency of men with genitourinary system cancers was approximately 2.1-fold higher than in women. The previous report stated that in males, genitourinary system tumors formed 17.5% of all the malignancies.,
Regarding to age in this study, with a minimum of 2 and a maximum of 110, the mean ± SD was 63.5 ± 15.8 years. This is in agreement with earlier reports, that confirmed a significant proportion of patients with genitourinary system those suffered in the middle-age.,
In this study, the frequency of genital system cancers was 1.43-fold higher than the frequency of urinary system cancers. In 2018, prostate cancer as the second most frequent malignancy counted for 1,276,106 new cases that caused 358,989 deaths worldwide.,, In this study, prostate cancer (n = 1648) was ranked as the first place among other men genitals. In addition, the frequency of testicular cancer (n = 147) and penile cancer was low (n = 5). This is in agreement with the previous publication that confirmed testicular cancer occurs in <1 man/100,000 populations  and the incidence of carcinoma of the penis is multifactorial and depends on various factors such as prevailing circumcision practice, number of sexual partners, prior HPV infection, and exposure to tobacco products.
Tumor of the female reproductive system such as the cervix, corpus uteri, ovarian, vulvar, vaginal, and choriocarcinoma are an important cause of morbidity and mortality worldwide. It is estimated to be the third most common group of malignancies in women., In this study, among genital system, the frequency of the most lethal female malignancies or ovary cancer (352 alive vs. 85 deaths); was higher than other parts.
Regarding to urinary system cancers, in this study, frequency of bladder cancer was higher than the other parts of the urinary system. This is in agreement with previous publications that confirmed urothelial carcinoma of urinary bladder cancer is the fourth most common cancer in men and eighth most common malignancy in women in the world., In addition, kidney cancer that corresponded to 348 alive versus 56 deaths was the second-ranked urinary system tumors in the population studied. In 2012, publication was reported an estimated value of 143,000 deaths by renal cell carcinoma.
Furthermore, the identification of high-risk groups that may benefit from scheduled-based program recommended.
| Conclusions|| |
This study shows a higher frequency of genitourinary system cancers in men than in women. In addition, the frequency of genital system cancers was higher than the frequency of urinary system cancers. In this study, the Iranian health system should consider the justification for a future approach toward genitourinary system cancers in terms of pharmacotherapy and surgery management. Further studies are recommended to improve the quality and quantity of life in these patients.
Financial support and sponsorship
Isfahan University of Medical Sciences supported this study of Ethics. Code No. of 295115.
Conflicts of interest
There are no conflicts of interest.
| References|| |
Yaxley JP. Urinary tract cancers: An overview for general practice. J Family Med Prim Care 2016;5:533-8.
] [Full text]
Yuvaraja TB, Waigankar S, Bakshi G, Prakash G. Genitourinary cancers: Summary of indian data. South Asian J Cancer 2016;5:122-4.
] [Full text]
Mazdak H, Tolou-Ghamari Z. Preliminary study of prevalence for bladder cancer in Isfahan province, Iran. Arab J Urol 2018;16:206-10.
Sharma RG, Kumar R, Jain S, Jhajhria S, Gupta N, Gupta SK, et al
. Distribution of malignant neoplasms reported at different pathology centers and hospitals in Jaipur, Rajasthan. Indian J Cancer 2009;46:323-30.
] [Full text]
McAninch J, Lue T. Smith and Tanagho's General Urology. 18th
ed. New York: McGraw Hill Companies Inc; 2013.
Okeke T, Onah N, Ikeako L, Ezenyeaku C. The frequency and pattern of female genital tract malignancies at the University of Nigeria teaching hospital, Enugu, Nigeria. Ann Med Health Sci Res 2013;3:345-8.
] [Full text]
Mirbahari SG, Sadeghi M. The prevalence of genus alpha human papillomavirus in women with uterine cervical infection and/or inflammation in Western Iran. Mater Sociomed 2018;30:113-7.
Heidarpour M, Derakhshan M, Derakhshan-Horeh M, Kheirollahi M, Dashti S. Prevalence of high-risk human papillomavirus infection in women with ovarian endometriosis. J Obstet Gynaecol Res 2017;43:135-9.
Bukowski RM. Genitourinary oncology: Current status and future challenges. Front Oncol 2011;1:32.
Tolou-Ghamari Z. Prevalence of kidney, renal pelvis, and ureter cancers in Isfahan province, Iran. J Arch Mil Med 2019;7:e95457.
Tolou Ghamari Z. Prevalence of lung cancer in isfahan province, Iran. J Egypt Natl Canc Inst 2018;30:57-9.
Ghamari ZT. Prevalence of stomach cancer in isfahan province, Iran. Gulf J Oncolog 2018;1:42-5.
Tolou Ghamari Z, Tadayon F, Mazdak H. Prevalence of liver cancer in Isfahan province, Iran. Indones J Cancer 2018;12:56-9.
Barman D, Sharma JD, Barmon D, Kataki AC, Sharma A, Kalita M, et al.
Epidemiology of gynecological cancers in Kamrup Urban district cancer registry. Indian J Cancer 2017;54:388-91.
] [Full text]
Rawla P. Epidemiology of prostate cancer. World J Oncol 2019;10:63-89.
Jain S, Saxena S, Kumar A. Epidemiology of prostate cancer in India. Meta Gene 2014;2:596-605.
Hassanipour-Azgomi S, Mohammadian-Hafshejani A, Ghoncheh M, Towhidi F, Jamehshorani S, Salehiniya H. Incidence and mortality of prostate cancer and their relationship with the human development index worldwide. Prostate Int 2016;4:118-24.
Elzinga-Tinke JE, Dohle GR, Looijenga LH. Etiology and early pathogenesis of malignant testicular germ cell tumors: Towards possibilities for preinvasive diagnosis. Asian J Androl 2015;17:381-93.
] [Full text]
Hakenberg OW, Dräger DL, Erbersdobler A, Naumann CM, Jünemann KP, Protzel C, et al.
The diagnosis and treatment of penile cancer. Dtsch Arztebl Int 2018;115:646-52.
Kamal R, Hamed S, Mansour S, Mounir Y, Abdel Sallam S. Ovarian cancer screening-ultrasound; impact on ovarian cancer mortality. Br J Radiol 2018;91:20170571.
Collaborative Group on Epidemiological Studies of Ovarian Cancer, Beral V, Gaitskell K, Hermon C, Moser K, Reeves G, et al.
Ovarian cancer and smoking: Individual participant meta-analysis including 28,114 women with ovarian cancer from 51 epidemiological studies. Lancet Oncol 2012;13:946-56.
Lin J, Spitz MR, Dinney CP, Etzel CJ, Grossman HB, Wu X. Bladder cancer risk as modified by family history and smoking. Cancer 2006;107:705-11.
Medina-Rico M, Ramos HL, Lobo M, Romo J, Prada JG. Epidemiology of renal cancer in developing countries: Review of the literature. Can Urol Assoc J 2018;12:E154-62.
[Figure 1], [Figure 2]