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ORIGINAL ARTICLE
Year : 2019  |  Volume : 8  |  Issue : 6  |  Page : 227-231

Expression of epidermal growth factor receptor in squamous cell carcinoma of uterine cervix


Department of Pathology, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, New Delhi, India

Correspondence Address:
Sompal Singh
Department of Pathology, North Delhi Municipal Corporation Medical College and Hindu Rao Hospital, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ccij.ccij_69_19

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Context: Cervical cancer is one of the most important cancer deaths among females. Epidermal growth factor receptor (EGFR) plays a role in cell differentiation, cell motility, neovascularization, invasion, metastasis, and resistance of cancer cells to chemotherapeutic agents and radiation. Tyrosine kinase inhibitors and anti-EGFR monoclonal antibodies have shown better response in various invasive tumors. Aims: The aim of the study is to evaluate EGFR expression in squamous cell carcinoma (SCC) of the cervix and to assess its relation to tumor characteristics. Settings and Design: This was a retrospective, case–control study. Subjects and Methods: Formalin-fixed paraffin-embedded tissues from 30 cases with SCC along with 20 age-matched cases with normal cervix as controls were obtained from the archives. EGFR expression was analyzed in both cases and controls. Statistical Analysis Used: The Chi-square test was used to compare and find the association between the variables. Statistical analysis was done using the IBM SPSS (IBM, Armonk, NY, USA) software and P < 0.05 was considered significant. Results: Strong EGFR expression was present in 93.4% of the cases, while 6.6% of cases showed moderate expression. Strong EGFR expression was associated with the tumor size of >4 cm size. There was no association of EGFR expression with tumor grade, tumor stage, and lymph node metastasis. Conclusions: The present study showed that a significantly higher number of cases of invasive SCC of uterine cervix show increased EGFR expression. The EGFR expression is associated with tumor size.


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