Expression patterns of cofilin and scinderin in breast cancer and their association with clinicopathological features in Iranian patients

Parisa Nourmohammadi; Mojtaba Saffari; Mohammad Hasan Sheikhha; Sara Tutunchi; Bahareh Nourmohammadi; Amirnader Emami Razavi; Reza Shirkoohi; Nasrin Ghasemi

doi:10.4103/ccij.ccij_52_19

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ORIGINAL ARTICLE

Year : 2019 | Volume : 8 | Issue : 6 | Page : 215-221

Expression patterns of cofilin and scinderin in breast cancer and their association with clinicopathological features in Iranian patients

Parisa Nourmohammadi¹, Mojtaba Saffari², Mohammad Hasan Sheikhha¹, Sara Tutunchi¹, Bahareh Nourmohammadi³, Amirnader Emami Razavi⁴, Reza Shirkoohi⁵, Nasrin Ghasemi⁶
¹ Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
² Department of Genetic, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
³ Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
⁴ Iran National Tumor Bank, Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
⁵ Cancer Research Center, Cancer Institute of Iran; Cancer Biology Research Center, Cancer Institute of Iran, Tehran, Iran
⁶ Recurrent Abortion Research Centre, Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Correspondence Address:
Nasrin Ghasemi
Recurrent Abortion Research Centre, Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd
Iran
Reza Shirkoohi
Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran
Iran

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/ccij.ccij_52_19

Background: Cofilin-1 (CLF1) and scinderin (SCIN) are significant actin-binding proteins that are involved in the regulation of the actin polymerization dynamics. Overexpression of CLF1 and SCIN has been associated with aggressive and tumorigenesis characteristics of various cancer types. The aim of the present study was to investigate the expression of CFL1 and SCIN genes in breast cancer cells and their association with clinicopathological features. Materials and Methods: In this study, 65 breast cancer tissues were randomly selected, and quantitative real-time polymerase chain reaction was performed to measure the expression level of CFL1 and SCIN genes in breast tumors. Then, the association of CFL1 and SCIN expression level with clinicopathological features was assessed using Prism 5 software. Results: Overexpression of CFL1 and SCIN was observed to be statistically significantly associated with tumor stage and lymph node involvement (P < 0.05). However, no association was found between the expression of the mentioned genes and tumor grade, tumor size, and patient age. Conclusion: The results of this study suggest that as CFL1 and SCIN genes may play a role in the development of breast cancer; they have the potential to be examined as new biomarkers to predict the progression of the mentioned disease.

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