Submit Your Article CMED MEACR meeting
Home Print this page Email this page Users Online: 1162
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2019  |  Volume : 8  |  Issue : 3  |  Page : 96-105

The effect of matrix metalloproteinases and adhesion molecules on the prognosis in gastric carcinoma


1 Department of Pathology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey
2 Department of Pathology, Faculty of Medicine, Acibadem University, İstanbul, Turkey

Correspondence Address:
Zehra Bozdag
Department of Pathology, Faculty of Medicine, Gaziantep University, Sahinbey, Gaziantep
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ccij.ccij_27_19

Rights and Permissions

Background: Matrix metalloproteinases (MMPs), adhesion molecules, and receptors are needed in the process of cancer growth. This study aims to investigate the role of MMP-3, MMP-10, MMP-11, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in gastric cancer. Materials and Methods: Fifty-two gastric carcinoma cases who underwent gastrectomy were included in the study. The cases were inspected with regard to the presence/absence of lymph node and distant metastases. The selected paraffin blocks were immunohistochemically stained with MMP 3, MMP 10, MMP 11, ICAM (CD 54), and VCAM (CD 106). Results: Most of the cases (n: 50, 94%) with gastric cancer manifested cytoplasmic staining with MMP-11. MMP-10 expression was found in 45 of 52 (86.5%), MMP-3 staining was determined in 43 (82.6%) of gastric carcinomas. Different areas of differentiation within the tumor showed differences in MMP expression in terms of intensity and extensiveness. ICAM-1 expression was found in 47 of 52 (90.4%) cases and with VCAM-1, 46/52 (88.5%) of gastric cancers manifested positive staining. Its expression was found to be higher in the nonmetastatic group both in intestinal and diffuse types. VCAM-1 was diffusely expressed in gastric cancers. However, we did not determine a significant correlation concerning differentiation and lymph node and distant metastasis. Conclusions: MMP-3, MMP-10, MMP-11, ICAM-1, and VCAM-1 are expressed in gastric cancers and are thought to be involved in tumor development. Levels of expression that decrease in parallel to decreasing differentiation in areas of differentiation within tumor corroborate the idea that they are related to tumor progression. Due to its relationship with metastasis, ICAM-1 expression in noncohesive cells supports the idea that ICAM-1 is a significant factor involved in metastasis development in gastric cancers. Decreased MMP-10 and MMP-11 expression in metastases suggest that these enzymes may also be linked to the metastatic potential of gastric cancers.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed116    
    Printed10    
    Emailed0    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal