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ORIGINAL ARTICLE
Year : 2019  |  Volume : 8  |  Issue : 2  |  Page : 47-51

Surgical margins and nodal metastasis are prognostic factors in oral squamous cell carcinoma: A meta-analysis


1 Department of Oral and Maxillofacial Surgery, Saveetha Dental College and Hospital, Chennai, Tamil Nadu, India
2 Department of Oral and Maxillofacial Oncology, Saveetha Dental College and Hospital, Chennai, Tamil Nadu, India
3 Consultant Radiation Oncologist, CHL-CBCC Cancer Centre, Indore, India
4 Consultant Histopathologist, CHL Hospitals, Indore, India
5 Consultant Oral and Maxillofacial Surgeon, Indore, India

Correspondence Address:
Mohammad Akheel
Saveetha Dental College and Hospital, Chennai, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ccij.ccij_21_19

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Background: To find out whether surgical margins and nodal metastasis are prognostic factors in oral squamous cell carcinoma (OSCC). Materials and Methods: PubMed search was done to look for studies done on surgical margins and nodal metastasis of OSCC from 2008 to 2018. Results: Fixed effects meta-analysis showed a pooled estimate absolute risk reduction of −3% (95% confidence interval [CI] [−8, 2.5%]). P =0.2819 from the fixed margin model shows no statistically significant difference between close margins with cases of deaths due to recurrence or metastasis. The pooled odds ratio was 0.87 (95% CI 0.63–1.99, P = 0.3928) for the comparison between clear and closed margins for estimating the odds. It should be noted that the mean unweighted local recurrence rate for margins 5 mm or greater was 4.9% with 95% CI as −10.7%, 0.8%. Conclusion: The study shows that close surgical margins with nodal metastasis have a poor prognosis in OSCC; however, no statistical significance was seen in this meta-analysis.


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