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ORIGINAL ARTICLE
Year : 2019  |  Volume : 8  |  Issue : 1  |  Page : 7-14

Is there correlation between CD19, CD20, and CD25 expressions with platelet changes within 6 months in children with immune thrombocytopenic purpura?


Thalassemia and Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Correspondence Address:
Dr. Najmaldin Saki
Thalassemia & Hemoglobinopathy Research Center, Research Institute of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz; Department of Clinical Laboratory, Allied Health Sciences School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz; Golestan Hospital, Ahwaz
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ccij.ccij_105_18

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Background: Immune thrombocytopenic purpura (ITP) is a bleeding disorder in which the defects of immune system cells play a vital role. The aim of this study was to explore the possible correlation between independent CD markers' expressions and platelet counts in children with ITP. Materials and Methods: The frequency of CD19, CD20, and CD25 markers in the peripheral blood of twenty children with ITP was investigated by flow cytometry, and the possible correlation between the expressions of these markers with platelet counts was analyzed. Results: A significant negative correlation was found between CD20 expression with platelet counts before (P = 0.024) and 10 days after treatment (P = 0.016). There was no significant correlation between the expressions of CD19 and CD25 with platelet counts at different times of follow-up. Moreover, CD20 expression was higher in patients with no response compared to those having complete response to first-line therapies. Conclusion: We found that the expressions of these markers could not be considered as a prognostic factor independent of other contributors involved in ITP pathogenesis. It is important that future studies should focus on the potential effects of other factors involved in ITP pathogenesis and their impact on response to therapy, as well as evaluating CD markers during ITP progression.


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