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ORIGINAL ARTICLE
Year : 2018  |  Volume : 7  |  Issue : 2  |  Page : 62-69

KAI-1 ad p53 Expression in Odontogenic Cysts: An Immunohistochemical Marker Study


1 Department of Oral Pathology and Microbiology, Saraswati-Dhanwantari Dental College and Hospital and Post-Graduate Research Institute, Parbhani, India
2 Department of Oral Pathology and Microbiology, Subharti Dental College and Hospital, Meerut, Uttar Pradesh, India
3 Department of Oral Medicine and Radiology, Saraswati-Dhanwantari Dental College and Hospital and Post-Graduate Research Institute, Parbhani, India
4 Department of Oral Pathology and Microbiology, Sharad Pawar Dental College and Hospital, Wardha, India
5 Department of Oral Pathology and Microbiology, Aditya Dental College and Hospital, Beed, Maharashtra, India
6 Department of Oral Pathology and Microbiology, Care Dental College and Hospital, Guntur, Andhra Pradesh, India

Correspondence Address:
Dr. Abhishek Singh Nayyar
44, Behind Singla Nursing Home, New Friends' Colony, Model Town, Panipat – 132 103, Haryana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ccij.ccij_3_17

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Background: KAI-1/CD82 is a tumor suppressor gene with decreased gene expression being associated with increased invasive ability of oral squamous cell carcinoma and as hypothesized for various odontogenic cysts and tumors. p53 protein functions in G1-S phase of the cell cycle to allow the repair of damaged DNA. In the present study, p53 and KAI-1 expression was investigated using monoclonal antibodies in the various odontogenic cysts. Aims: To detect KAI-1 and p53 expression in radicular cysts, dentigerous cysts, and odontogenic keratocysts (OKCs) and to assess the relation between p53 and KAI-1 expression in the aforementioned cysts. Materials and Methods: The present study included histopathologically diagnosed cases of radicular cysts, dentigerous cysts, and OKCs for the expression of KAI-1 and p53 antibodies. Results: Among odontogenic cysts, radicular cysts expressed maximum positivity of KAI-1 (20.92%) while p53-positive cells were maximum in OKC (4.04%). The correlation between KAI-1 and p53 expression in the various odontogenic cysts was not found to be significant. Conclusion: The increased KAI-1 expression in the radicular cysts and its downregulation in OKCs may be indicative of aggressive clinical behavior and the fact that OKCs are hypothesized as neoplastic rather than being developmental in origin.


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