Advertisment CMED
Home Print this page Email this page Users Online: 122
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 


 
 Table of Contents  
CASE REPORT
Year : 2017  |  Volume : 6  |  Issue : 3  |  Page : 171-173

Colitis cystica profunda mimicking adenocarcinoma


Department of Pathology, Grant Government Medical College and Sir J.J. Hospital, Mumbai, Maharashtra, India

Date of Web Publication29-Sep-2017

Correspondence Address:
Sameer A. H. Ansari
Grant Medical College and Sir J.J. Hospital, Mumbai - 400 008, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ccij.ccij_33_17

Rights and Permissions
  Abstract 


Colitis cystica profunda is a rare benign condition of the rectum and colon and is characterized by benign intramural mucous containing glands. It can be easily misdiagnosed as invasive adenocarcinoma clinically as well as on imaging modalities. The definite diagnosis can only be made on histopathology. We present a case of 50-year-old male who came with the complaints of intermittent abdominal pain and abdominal distension.

Keywords: Adenocarcinoma, colitis cystica profunda, colon, rectum


How to cite this article:
Ansari SA, Ramraje SN, D'Costa GF. Colitis cystica profunda mimicking adenocarcinoma. Clin Cancer Investig J 2017;6:171-3

How to cite this URL:
Ansari SA, Ramraje SN, D'Costa GF. Colitis cystica profunda mimicking adenocarcinoma. Clin Cancer Investig J [serial online] 2017 [cited 2017 Oct 18];6:171-3. Available from: http://www.ccij-online.org/text.asp?2017/6/3/171/215829




  Introduction Top


Colitis cystica profunda (CCP) is an extremely rare benign lesion of the large intestine. It is commonly seen in the rectum and sigmoid colon but can also be seen anywhere throughout the colon.[1] It shows male predilection and is characterized by submucosal mucin filled cyst lined by benign epithelium. Although the cause of this lesion is still not clear, it occurrence always poses difficulty as it closely mimic adenocarcinoma both clinically as well as on imaging, and can lead to unnecessary radical surgery and aggressive management.[1],[2],[3] The diagnosis of this condition require a high degree of suspicion and adequate biopsies to avoid unnecessary aggressive surgery.


  Case Report Top


A 50-year-old male came to the outpatient department with complaints of intermittent abdominal pain and distension since 7–8 months. He started developing intermittent abdominal bloating and distension 7–8 months back that gradually was followed by pain in abdomen which was mild in intensity, colicky, generalized not associated with any aggravating and relieving factor. He also complained of altered bowel habits in this period. However, he did not give any history of malena, diarrhea, and hematuria. The patient is a known case of abdominal Koch's and had completed treatment. The patient had no significant family history of bowel pathology. Computerized Tomography of the abdomen and pelvis revealed a circumferential thickening of caecum and distal ileum along with dilatation of distal ileum [Figure 1] suggesting malignancy. Right hemicolectomy was done. On gross examination, the right hemicolectomy specimen showed a focally thickened wall which was grayish-white firm on cut surface [Figure 2]. No ulceration, tubercles or lymph nodes were identified. Microscopic examination of the thickened gray white area was done. It revealed entrapped glands in the muscularis propria [Figure 3]. The glands were cystically dilated, contained mucin and were lined by bland appearing columnar cells having round to oval nuclei and moderate amount of eosinophilic cytoplasm [Figure 4]. Extracellular mucin pools were also seen. However, no evidence of any dysplasia or malignancy. The patient tolerated the procedure well and follow-up was uneventful.
Figure 1: Computerized Tomography of the abdomen and pelvis revealed a circumferential thickening of caecum and distal ileum along with dilatation of distal ileum

Click here to view
Figure 2: Right hemi colectomy specimen showed a focally thickened wall, grayish-white firm in consistency

Click here to view
Figure 3: Microscopic examination revealed entrapped glands in the muscularis propria

Click here to view
Figure 4: The glands are cystically dilated, contained mucin and were lined by bland appearing columnar cells having round to oval nuclei and moderate amount of eosinophilic cytoplasm

Click here to view



  Discussion Top


CCP is a very intriguing benign lesion of the colon. Stark [4] first described this lesion in an autopsy study of two patients. Later on, Virchow [5] introduced the term CCP in a case report of multiple polypoidal cystic submucosal lesions. The most common site of CCP is rectum and sigmoid colon. The etiology of this condition is still not known, but proposed theory is of congenital origin. It is also seen with other acquired conditions such as solitary rectal ulcer, inflammatory bowel disease, diverticulitis, local rectal trauma, and rectal prolapse. Its uncommon association with reported cases of adenocarcinoma has made it mandatory to look and search thoroughly to rule out such possibilities.[1],[6]

On gross examination, the colonic wall appears thickened and shows cyst in the submucosa.[1] On histopathology, mucin filled cysts are seen in the muscularis propria which can be localized forming a polypoidal lesion or can be diffusely distributed through the length of the colon.[7] In both lesions mucosal ulceration and inflammation can be seen. The localized form is usually seen in solitary rectal ulcer and rectal prolapse,[1] whereas diffuse form is associated with colitis, radiation, and infective colitis.[6],[7] Patients may be asymptomatic or may present with symptoms of rectal bleeding, mucus discharge, tenesmus, proctalgia fugax, and altered bowel habits.[1],[2],[8] Endoscopy reveals a polypoidal lesion covered by unremarkable or ulcerated mucosa.[1] Endoscopic anorectal ultrasound helps in suggesting the diagnosis as it shows hypoechoic signal in the submucosal layer without deeper infiltration. Computerized Tomography and Magnetic resonance imaging show a noninfiltrating submucosal cystic lesion with some loss of perirectal fatty tissue. Histopathology is the gold standard to differentiate malignancy from this benign lesion.[1] The differential diagnosis and close mimics of this condition are invasive adenocarcinoma and endometriosis.[9] However, the bland cytological features of the entrapped benign glands can be easily distinguished and help to rule out malignancy.[9] Endometriosis can be differentiated by the presence of small round tubular glands accompanied by endometrial stroma. Treatment is usually conservative and surgical intervention is reserved for those cases which show no improvement in the symptoms and are associated with rectal prolapse.[1] Operative options include transanal excision of CCP, rectal mucosal excision (Delorme's Operation) perineal rectosigmoidectomy (Altermeier's operation) with coloanal anastomosis, stapled transmural resection of rectum (STAAR procedure), and abdominal approach laparoscopic ventral rectopexy.[1],[2],[10]


  Conclusion Top


Although extremely uncommon, this entity should be kept in mind as it mimics adenocarcinoma both clinically as well as on investigative modalities. Furthermore, the treatment modalities and outcome totally changes in both the lesions.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Ayantunde AA, Strauss C, Sivakkolunthu M, Malhotra A. Colitis cystica profunda of the rectum: An unexpected operative finding. World J Clin Cases 2016;4:177-80.  Back to cited text no. 1
    
2.
Kayaçetin E, Kayaçetin S. Colitis cystica profunda simulating rectal carcinoma. Acta Chir Belg 2005;105:306-8.  Back to cited text no. 2
    
3.
Kornprat P, Langner C, Pfeifer J, Mischinger HJ. Colitis cystica profunda associated with rectal prolapse: Report of a case. Int J Colorectal Dis 2007;22:1555-6.  Back to cited text no. 3
    
4.
Stark W. Specimen Septemhistoriaset Dissections Dysentoricumexhibens (Thesis). The Netherlands: Leiden; 1966.  Back to cited text no. 4
    
5.
Virchow R. Die Krankhaften Geschwulste. Berlin: Hirschwald; 1963.  Back to cited text no. 5
    
6.
de Toro CG, Villaseca HM, Roa SJ. Colitis cystica profunda: Report of one case. Rev Med Chil 2007;135:759-63.  Back to cited text no. 6
    
7.
Qayed E, Srinivasan S, Wehbi M. A case of colitis cystica profunda in association with diverticulitis. Am J Gastroenterol 2011;106:172-3.  Back to cited text no. 7
    
8.
Wang F, Frisbie JH, Klein MA. Solitary rectal ulcer syndrome (colitis cystica profunda) in spinal cord injury patients: 3 case reports. Arch Phys Med Rehabil 2001;82:260-1.  Back to cited text no. 8
    
9.
De Petris G, Leung ST. Pseudoneoplasms of the gastrointestinal tract. Arch Pathol Lab Med 2010;134:378-92.  Back to cited text no. 9
    
10.
Beck DE. Surgical therapy for colitis cystica profunda and solitary rectal ulcer syndrome. Curr Treat Options Gastroenterol 2002;5:231-7.  Back to cited text no. 10
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]



 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
Abstract
Introduction
Case Report
Discussion
Conclusion
References
Article Figures

 Article Access Statistics
    Viewed88    
    Printed3    
    Emailed0    
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal