Submit Your Article CMED MEACR meeting
Home Print this page Email this page Users Online: 927
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 


 
 Table of Contents  
LETTER TO THE EDITOR
Year : 2015  |  Volume : 4  |  Issue : 2  |  Page : 292-293

Is multiparity a protective mechanism in Iraqi females with breast cancer? Need for detailed analysis


Department of Radiation Oncology, Artemis Health Institute, Gurgaon, Haryana, India

Date of Web Publication9-Mar-2015

Correspondence Address:
Vivek Tiwari
Department of Radiation Oncology, Artemis Health Institute, Sector 51, Gurgaon, Haryana
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-0513.148933

Rights and Permissions

How to cite this article:
Tiwari V, Pande SC, Verma K, Goel S. Is multiparity a protective mechanism in Iraqi females with breast cancer? Need for detailed analysis. Clin Cancer Investig J 2015;4:292-3

How to cite this URL:
Tiwari V, Pande SC, Verma K, Goel S. Is multiparity a protective mechanism in Iraqi females with breast cancer? Need for detailed analysis. Clin Cancer Investig J [serial online] 2015 [cited 2019 Oct 14];4:292-3. Available from: http://www.ccij-online.org/text.asp?2015/4/2/292/148933

Sir,

Breast cancer (BC) is the most frequent cancer in women both in developed and developing countries. [1] It is also the most frequent cancer among women in Iraq and in accordance with the latest Iraqi Cancer Registry, BC accounts for approximately one-third of the registered female cancers making it the leading cancer site. [2]

Studies have suggested that higher age at first pregnancy, number of children and the lapse between births may protect against BC. Serum levels of estrogen, prolactin, and progesterone have been found to contribute to the development of this tumor in obese women. [3] Furthermore, heterogeneity in reproductive risk factors also accounts for the distinct subtypes of BC. The most consistent evidence has been that for hormone receptor (HR) positive BC with multiparity, use of menopausal hormone therapy, and prolonged interval between menarche and age at childbearing being the strongest risk factors, while multiparity and lactation being inversely associated with HR positive tumors [4] In an attempt to recognize the possible risk, as well as protective factors associated with BC in Iraqi females, we undertook a retrospective audit of 50 Iraqi females who were referred to us for adjuvant radiotherapy.

In our analysis (n = 50), the mean age of the group was 47.93 (range 24-69) years. Of these, 21 females (42%) were premenopausal whereas 29 (48%) were postmenopausal. Seven females (14%) had a triple negative hormonal status. Three females (6%) had Stage I disease, 16 (32%) had Stage II disease, 26 females (52%) had a Stage III disease and five females (10%) had a Stage IV disease diagnosed on metastatic workup.

Of particular interest was the fact that 25 out of 48 (52.08%) females had ≥4 child births while 23 (47.91%) females had ≤3 child births. Multiple pregnancies did not appear to confer any protection in the group studied.

Literature research reveals a host of factors that have been postulated to be associated in one form or the other with BC affecting females in Iraq. These include seemingly farfetched determinants viz. estimation of serum prostate-specific antigen [5] or antiperspirant use [6] with no evidence towards postulating any protective factors. Similarly, in our brief analysis, we found out no definite correlation between the number of pregnancies and the occurrence of BC in the Iraqi females.

Given the alarming rise of BC incidence in Iraq, there seems to be an urgent need to postulate the possible risk factors contributing, and aid an efficient prevention. The altered ecosystem owing to warfare, prevalence of smoking, viral factors and/or possible dietary and environmental factors may account for the probable cause. [7],[8],[9]

Our data does not clearly indicate any particular factor or pattern as a risk of BC in the Iraqi females but at the same time, suggests no definite prevention in females having multiple (mostly >4) pregnancies and subsequent breast-feeding.

This letter comes as a recommendation to formulate a robust database and to expand epidemiological research needed to examine possible causes and prevention of the same. We recommend large investigational studies addressing the particular risk factors affecting the Iraqi females as a causative mechanism for BC with multiparity appearing to offer little, if not none, benefit.


  Acknowledgment Top


Ms. Navita Gill, Radiation Oncology Nurse.

 
  References Top

1.
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127:2893-917.  Back to cited text no. 1
    
2.
Al-Hashimi MM, Wang XJ. Breast cancer in Iraq, incidence trends from 2000-2009. Asian Pac J Cancer Prev 2014;15:281-6.  Back to cited text no. 2
    
3.
González-Jiménez E, Montero-Alonso MÁ, Schmidt Riovalle J. Association between obstetric factors, hormone levels and nutritional status with the development of breast cancer. Rev Med Chil 2013;141:1541-6.  Back to cited text no. 3
    
4.
Anderson KN, Schwab RB, Martinez ME. Reproductive risk factors and breast cancer subtypes: A review of the literature. Breast Cancer Res Treat 2014;144:1-10.  Back to cited text no. 4
    
5.
Mashkoor FC, Al-Asadi JN, Al-Naama LM. Serum level of prostate-specific antigen (PSA) in women with breast cancer. Cancer Epidemiol 2013;37:613-8.  Back to cited text no. 5
    
6.
Fakri S, Al-Azzawi A, Al-Tawil N. Antiperspirant use as a risk factor for breast cancer in Iraq. East Mediterr Health J 2006;12:478-82.  Back to cited text no. 6
    
7.
El-Basmy A, Al-Mohannadi S, Al-Awadi A. Some epidemiological measures of cancer in Kuwait: National cancer registry data from 2000-2009. Asian Pac J Cancer Prev 2012;13:3113-8.  Back to cited text no. 7
    
8.
Al Moustafa AE, Al-Awadhi R, Missaoui N, Adam I, Durusoy R, Ghabreau L, et al. Human papillomaviruses-related cancers: Presence and prevention strategies in the Middle East and North African Regions. Hum Vaccin Immunother 2014;10.  Back to cited text no. 8
    
9.
Dhaini HR, Kobeissi L. Toxicogenetic profile and cancer risk in Lebanese. J Toxicol Environ Health B Crit Rev 2014;17:95-125.  Back to cited text no. 9
    



This article has been cited by
1 The impact of age on antimullerian hormone serum level in women attending chemotherapy Unit for primary breast cancer
Hawraa Talib Al-Janabi,Hanan A. Al-Taee,Alaa Sadq Alawad
Middle East Fertility Society Journal. 2017;
[Pubmed] | [DOI]
2 Breast Cancer in Western Iraq: Clinicopathological Single Institution Study
Arkan Obaid Jasim Al-Isawi
Advances in Breast Cancer Research. 2016; 05(02): 83
[Pubmed] | [DOI]



 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
Acknowledgment
References

 Article Access Statistics
    Viewed1175    
    Printed22    
    Emailed1    
    PDF Downloaded23    
    Comments [Add]    
    Cited by others 2    

Recommend this journal