|LETTER TO THE EDITOR
|Year : 2015 | Volume
| Issue : 2 | Page : 292-293
Is multiparity a protective mechanism in Iraqi females with breast cancer? Need for detailed analysis
Vivek Tiwari, Subodh C Pande, Kamal Verma, Sandeep Goel
Department of Radiation Oncology, Artemis Health Institute, Gurgaon, Haryana, India
|Date of Web Publication||9-Mar-2015|
Department of Radiation Oncology, Artemis Health Institute, Sector 51, Gurgaon, Haryana
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Tiwari V, Pande SC, Verma K, Goel S. Is multiparity a protective mechanism in Iraqi females with breast cancer? Need for detailed analysis. Clin Cancer Investig J 2015;4:292-3
|How to cite this URL:|
Tiwari V, Pande SC, Verma K, Goel S. Is multiparity a protective mechanism in Iraqi females with breast cancer? Need for detailed analysis. Clin Cancer Investig J [serial online] 2015 [cited 2020 Feb 22];4:292-3. Available from: http://www.ccij-online.org/text.asp?2015/4/2/292/148933
Breast cancer (BC) is the most frequent cancer in women both in developed and developing countries.  It is also the most frequent cancer among women in Iraq and in accordance with the latest Iraqi Cancer Registry, BC accounts for approximately one-third of the registered female cancers making it the leading cancer site. 
Studies have suggested that higher age at first pregnancy, number of children and the lapse between births may protect against BC. Serum levels of estrogen, prolactin, and progesterone have been found to contribute to the development of this tumor in obese women.  Furthermore, heterogeneity in reproductive risk factors also accounts for the distinct subtypes of BC. The most consistent evidence has been that for hormone receptor (HR) positive BC with multiparity, use of menopausal hormone therapy, and prolonged interval between menarche and age at childbearing being the strongest risk factors, while multiparity and lactation being inversely associated with HR positive tumors  In an attempt to recognize the possible risk, as well as protective factors associated with BC in Iraqi females, we undertook a retrospective audit of 50 Iraqi females who were referred to us for adjuvant radiotherapy.
In our analysis (n = 50), the mean age of the group was 47.93 (range 24-69) years. Of these, 21 females (42%) were premenopausal whereas 29 (48%) were postmenopausal. Seven females (14%) had a triple negative hormonal status. Three females (6%) had Stage I disease, 16 (32%) had Stage II disease, 26 females (52%) had a Stage III disease and five females (10%) had a Stage IV disease diagnosed on metastatic workup.
Of particular interest was the fact that 25 out of 48 (52.08%) females had ≥4 child births while 23 (47.91%) females had ≤3 child births. Multiple pregnancies did not appear to confer any protection in the group studied.
Literature research reveals a host of factors that have been postulated to be associated in one form or the other with BC affecting females in Iraq. These include seemingly farfetched determinants viz. estimation of serum prostate-specific antigen  or antiperspirant use  with no evidence towards postulating any protective factors. Similarly, in our brief analysis, we found out no definite correlation between the number of pregnancies and the occurrence of BC in the Iraqi females.
Given the alarming rise of BC incidence in Iraq, there seems to be an urgent need to postulate the possible risk factors contributing, and aid an efficient prevention. The altered ecosystem owing to warfare, prevalence of smoking, viral factors and/or possible dietary and environmental factors may account for the probable cause. ,,
Our data does not clearly indicate any particular factor or pattern as a risk of BC in the Iraqi females but at the same time, suggests no definite prevention in females having multiple (mostly >4) pregnancies and subsequent breast-feeding.
This letter comes as a recommendation to formulate a robust database and to expand epidemiological research needed to examine possible causes and prevention of the same. We recommend large investigational studies addressing the particular risk factors affecting the Iraqi females as a causative mechanism for BC with multiparity appearing to offer little, if not none, benefit.
| Acknowledgment|| |
Ms. Navita Gill, Radiation Oncology Nurse.
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