Submit Your Article CMED MEACR meeting
Home Print this page Email this page Users Online: 338
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Year : 2014  |  Volume : 3  |  Issue : 4  |  Page : 293-298

Significance of correlation between levels of carcinoembryonic antigen and carbohydrate antigen 19-9, carcinoembryonic antigen and C-reactive protein, carcinoembryonic antigen and alpha-1 antitrypsin in gastric and colon cancer patients

1 Department of Biochemistry, S. M. S. Medical College and Hospital, Jaipur, Rajasthan, India
2 Department of Pathology, S. M. S. Medical College and Hospital, Jaipur, Rajasthan, India
3 Department of Radiotherapy and Oncology, S. M. S. Medical College and Hospital, Jaipur, Rajasthan, India
4 Department of Research and Development Advanced Bioinformatics Centre, Birla Institute of Scientific, Research, Jaipur, Rajasthan, India

Correspondence Address:
Bhawna Bagaria
Department of Biochemistry, S. M.S. Medical College and Hospital, Jaipur - 302 004, Rajasthan
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2278-0513.134477

Rights and Permissions

Aim: Recent progress in proteomics studies profiled that serum proteins of cancer patients and those of normal individuals have altered cancer antigen and acute phase protein expression for distinct types and stages of cancer. In our study, correlation between carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9, CEA and C-reactive protein (CRP), CEA and alpha-1 antitrypsin (A1AT) were evaluated in gastric and colon cancer patients. Materials and Methods: CEA was estimated by solid phase, two-site sequential chemiluminescent immunometric assay, CA19-9 by solid phase enzyme-linked immunosorbent assay, CRP by latex turbidimetry method and A1AT by turbidimetry method. Results: A significant correlation was seen in levels of CEA and CA19-9 in gastric (r = 0.457, P < 0.001) and colon cancer (r = 0.451, P < 0.001) patients. Correlation between CEA and CRP was significant in gastric (r = 0.462, P < 0.001) and colon cancer (r = 0.759, P < 0.001) patients and between CEA and A1AT also, correlation was found to be significant in gastric (r = 0.631, P < 0.001) and colon cancer patients (r = 0.516, P ≤ 0.001). Conclusion: Serum acute-phase protein concentrations, when combined with CEA increases the sensitivity of CEA and provide substantial information concerning the diagnosis of gastrointestinal cancers. They have a definite role as a significant prognostic indicator which undoubtedly correlates with progression of cancer. Combined CEA and CA19-9 positivity reflected more biologic malignant properties and were significantly correlated with lymph node metastasis, hepatic metastasis and lower rates of curative resection. Surgical outcomes of patients who were CEA and CA19-9 positive were poorer than those of patients with normal CEA and CA19-9 levels.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded83    
    Comments [Add]    
    Cited by others 2    

Recommend this journal