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 Table of Contents  
CASE REPORT
Year : 2014  |  Volume : 3  |  Issue : 2  |  Page : 185-186

Benign mesenchymoma of foot: A rare occurrence


Department of Pathology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India

Date of Web Publication9-Apr-2014

Correspondence Address:
Kavita Mardi
12-A, Type V Quarters, GAD Colony, Kasumpti, Shimla, Himachal Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-0513.130224

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  Abstract 

Benign mesenchymomas comprising of two or more mesenchymal elements along with fibrous tissue are extremely rare soft tissue tumors. Their occurrence in foot is extremely rare with only one case reported so far. We report on such case of benign mesenchymoma in the foot of 27-year-old male. Microscopic examination of excised mass revealed islands of hyaline cartilage, bone, adipose tissue, and blood vessels embedded in fibrous tissue.

Keywords: Benign, foot, mesenchymoma, soft tissue


How to cite this article:
Mardi K. Benign mesenchymoma of foot: A rare occurrence. Clin Cancer Investig J 2014;3:185-6

How to cite this URL:
Mardi K. Benign mesenchymoma of foot: A rare occurrence. Clin Cancer Investig J [serial online] 2014 [cited 2020 Apr 1];3:185-6. Available from: http://www.ccij-online.org/text.asp?2014/3/2/185/130224


  Introduction Top


Benign mesenchymomas are exceptionally rare benign tumors composed of two or more nonepithelial mesenchymal elements along with fibrous tissue. [1] Soft tissue mesenchymomas are still rarer. [2] We report one such rare occurrence in the left foot of a 27-year-old male.


  Case Report Top


A 27-year-old male presented with a slow-growing painless soft tissue mass on the sole of left foot since 2 years.

On examination, a soft mass was felt on the left sole about 5 cm in diameter. It was not adherent to bone. The X-ray demonstrated that the tumor was well-circumscribed and noninfiltrating. It contained areas of calcification and did not involve bone. The tumor was excised. On gross examination, the specimen measured 5.5 × 5.5 × 3.8 cm. The cut surface showed lobulated cartilage with areas of calcification and ossification. Histologically, the findings were those of a mixture of cartilage, bone, mature adipose tissue, and blood vessels [Figure 1]. The cartilaginous tissue contained areas of calcification and bone formation. On follow-up after 6 months, no recurrence was evident.
Figure 1: Photomicrograph revealing island of hyaline cartilage and bone in fibrous tissue (H and E, ×40)

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  Discussion Top


Soft tissue mesenchymoma is an exceptionally rare benign neoplasm. [1],[2] Benign mesenchymoma is a soft tissue tumor that contains two or more differentiated mesenchymal components in addition to fibrous tissue.

In 1948, Stout coined the term mesenchymoma. [3] However, this original description inappropriately described a collection of 8 malignant mixed mesenchymal tumors. Possible mature mesenchymal elements that can be seen in benign mesenchymomas include muscle, fat, blood vessels, cartilage and/or myxomatous tissue. This possible variety of tissues that can be present in a mesenchymoma and occasional predominance of a single element has further added to the challenge of consistent nomenclature.

Benign mesenchymomas are typically found in variable locations such as the mesentery, skin, liver and ovary. [3] Soft tissue mesenchymomas are exceptionally rare. [2] Only one case of benign mesenchymoma has been reported in foot. [4] Since the description by Le Ber and Stout, [5] only 7 additional cases of hyaline cartilage predominant appendicular mesenchymomas have been reported [2],[6],[7],[8],[9] and of these, only 2 patients were skeletally immature. [5],[8] These case reports describe benign mesenchymomas in the forearm, [4] palm, [5] hip, [6] knee, [6] heel, [6] thigh, [7] and sole of the foot. The mature mesenchymal tissues reported in these benign mesenchymomas included fat, blood vessels, smooth muscles, striated muscle, cartilage, lymphoid and hematopoietic tissue. [5]

Controversy does exist regarding the true nature of benign mesenchymomas. Benign mesenchymomas have currently neither been recognized nor defined by the World Health Organization classification of soft-tissue tumors. These tumors have been labeled as hamartomas since they comprise of disorganized mass of tissues normally occurring in their site of origin. However, some of the potential constituents of benign mesenchymomas include hyaline cartilage, a tissue not normally found in soft tissue. For this reason, as well as possibility of reccurrence, [4] some clinicians instead classify benign mesenchymomas as a neoplasm. Regardless of the nomenclature, agreement exists that benign mesenchymomas have no relation to malignant mesenchymomas.

Stout [3] stated that the tumor occurred in both benign and malignant forms and that while the benign form was capable of local recurrences, the malignant form may have distant metastasis. Benign mesenchymomas may be associated with morbidity as a result of local infiltrative growth. [9]


  Conclusion Top


Soft tissue mesenchymoma is an exceptionally rare neoplasm. The histological finding of even small amounts of mesenchymal elements other than cartilage provides a basis for recognition of this rare but distinctive pathological entity.

 
  References Top

1.Argintar E, SandersT, Nomikos G, Henshaw R, Delahay J. Soft-tissue benign mesenchymoma in a pediatric patient. Am J Orthop 2012;41:561-4.  Back to cited text no. 1
    
2.Takato T, Soyano S, Naka Y, Mishina M. Benign mesenchymoma of the sole. Ann Plast Surg 1984;13:150-3.  Back to cited text no. 2
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3.Stout AP. Mesenchymoma, the mixed tumor if mesencymal derivatives. Ann Surg 1948;127:278-90.  Back to cited text no. 3
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4.Bugg EI, Mathews RS. Benign mesenchymoma. South Med J 1970;63:268-73.  Back to cited text no. 4
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5.Le Ber MS, Stout AP. Benign mesenchymomas in children. Cancer 1962;15:598-605.  Back to cited text no. 5
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6.Dorfman HD, Levin S, Robbins H. Cartilage-containing benign mesenchymomas of soft tissue. Report of two cases. J Bone Joint Surg Am 1980;6:472-5.  Back to cited text no. 6
    
7.Candocia FJ, Barlev DM. Chondrolipoma in the palm of a child: Sonographic and MR findings. Clin Imaging 2004;28:206-8.  Back to cited text no. 7
    
8.Milchgrub S, McMurry NK, Vuitch F, Dorfman HD. Chondrolipoangioma. A cartilage-containing benign mesenchymoma of soft tissue. Cancer 1990;66:2636-41.  Back to cited text no. 8
    
9.Ganzer D, Follak N, Lorenz G. Cartilage and bone containing benign mesenchymoma of the thigh and popliteal fossa. Int Orthop 2000;24:115-7.  Back to cited text no. 9
    


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Discussion
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