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COMMENTARY
Year : 2012  |  Volume : 1  |  Issue : 4  |  Page : 181-183

Fasting inhibits human cancer progression via the epithelial-mesenchymal transition process: Important evidence unraveled


Department of Mechanical Engineering, Concordia University and Oncology Department, McGill University, Montreal, Quebec, Canada, and Syrian Research Cancer Center of the Syrian Society against Cancer, Aleppo, Syria

Correspondence Address:
Ala-Eddin Al Moustafa
Department of Mechanical and Industrial Engineering, Concordia University, Sir George William Campus/EV 12.150, 1515, St. Catherine West, Montreal, QC, Canada H3G 2W1

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Source of Support: The research works from Dr. Al Moustafa’s laboratory have been supported by the Canadian Institutes for Health Research, (CIHR) the Cancer Research Society Inc. of Canada, the National Colorectal Cancer Campaign, and the Fonds de la Recherche en Santé du Québec (FRSQ- Réseau du Cancer),, Conflict of Interest: None


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Metastatic cancer disease is responsible for the majority of cancer-related deaths in human cancer patients. In parallel, recently it was pointed-out that fasting could play an important role during cancer treatment and progression via the deregulation of insulin-like growth factor-1 (IGF-1) as well as others growth factors and genes. Meanwhile, it is established that the epithelial-mesenchymal transition (EMT) is a major process for the progression of cancer cells from non-invasive to invasive form. We believe that fasting can inhibit cancer progression and metastasis though the reduction of IGF-1 level and consequently the inhibition of EMT; in this paper, we present some evidence to confirm this association.


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