Submit Your Article CMED MEACR meeting
Home Print this page Email this page Users Online: 1698
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2012  |  Volume : 1  |  Issue : 3  |  Page : 140-144

Immunohistochemical assessment of the effect of tobacco on a molecular gatekeeper in oral squamous cell carcinoma


1 Department of Oral Pathology, Rishiraj College of Dental Sciences and Research Centre, Bhopal, India
2 Oral Pathologist, Shimoga, Karnataka, India
3 Department of Oral Medicine and Radiology, School of Dental Sciences, Krishna Institute of Medical Sciences, Deemed University, Karad, Satara, Maharashtra, India

Correspondence Address:
K V Suresh
Department of Oral Medicine and Radiology, School of Dental Sciences, Krishna Institute of Medical Sciences, Deemed University, Karad, Satara, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-0513.102882

Rights and Permissions

Background: It has been emphasized that the molecular gatekeeper p53 has a key role in carcinogenesis and its mutation is seen in more than 50% of the human cancers including head and neck carcinomas and tobacco is the most important etiological agent in head and neck cancer. Aims: To assess p53 mutations in relation to tobacco usage in oral squamous cell carcinoma (OSCC) to understand the role of tobacco in the complex process of carcinogenesis. Materials and Methods: Forty formalin-fixed paraffin-embedded archival tissue samples were taken, of which 20 cases were associated with tobacco and 20 were not, and assessed immunohistochemically. Results: Enhanced expression of p53 was found to be associated with tobacco. Conclusions: p53 mutations are etiologically associated with the development of head and neck carcinomas and are associated with exposure to specific carcinogens of tobacco.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1234    
    Printed80    
    Emailed1    
    PDF Downloaded117    
    Comments [Add]    

Recommend this journal