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REVIEW ARTICLE
Year : 2012  |  Volume : 1  |  Issue : 1  |  Page : 6-12

Nanogoldtechnology-imaging, sensing and target therapy in head and neck cancer


1 Department of Oral Medicine and Radiology, Vydehi Institute of Dental Sciences, Bangalore, India
2 Department of Maxillofacial Surgery, Vydehi Institute of Dental Sciences, Bangalore, India

Correspondence Address:
Nishat Sultana
No-37, 1st Cross, Silver Oak Street, JP Nagar, 7th Phase, Bangalore - 78
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-0513.95012

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Innovation in the last decade has endowed nanotechnology with an assortment of tools for delivery, imaging, and sensing in cancer research. Cancer nanotherapeutics are rapidly progressing and are being implemented to solve several limitations of conventional drug delivery systems such as nonspecific biodistribution and targeting, lack of water solubility, poor oral bioavailability, and low therapeutic indices. To improve the biodistribution of cancer drugs, nanoparticles have been designed for optimal size and surface characteristics to increase their circulation time in the bloodstream. Nanoparticles have the ability to accumulate in cells without being recognized by P-glycoprotein, one of themainmediators of multidrug resistance, resulting in the increased intracellular concentration of drugs. Multifunctional and multiplex nanoparticles are now being actively investigated and are on the horizon as the next generation of nanoparticles, facilitating personalized and tailored cancer treatment.


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