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ORIGINAL ARTICLE
Year : 2012  |  Volume : 1  |  Issue : 1  |  Page : 26-30

High-risk human papillomavirus infections in colorectal cancer in the Syrian population and their association with Fascin, Id-1 and P-cadherin expressions: A tissue microarray study


1 Department of Pathology, Faculty of Medicine/University of Aleppo; Syrian Research Cancer Centre of the Syrian Society against Cancer, Aleppo, Syria
2 Segal Cancer Centre of the Lady Davis Institute/JGH/McGill University, Montreal, Quebec, Canada
3 Syrian Research Cancer Centre of the Syrian Society against Cancer, Aleppo, Syria; Segal Cancer Centre of the Lady Davis Institute/JGH/McGill University; Department of Oncology, McGill University; and Department of Mechanical Engineering, Concordia University, Montréal, Quebec, Canada

Correspondence Address:
Ala-Eddin Al Moustafa
Department of Mechanical and Industrial Engineering, Concordia University, 1455 Maisonneuve Blvd., West, Montreal, QC, H3G 1M8, Canada

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Source of Support: Canadian Institutes for Health Research and the Fonds de la Recherche en Santé du Québec (FRSQ- Réseau du Cancer),, Conflict of Interest: None


DOI: 10.4103/2278-0513.95016

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Background: High-risk human papillomaviruses (HPVs) can be regarded as important risk factors for colorectal carcinogenesis and metastasis. Alternatively, earlier studies have reported that Fascin, Id-1 and P-cadherin genes are important regulators of cell invasion and metastasis in several human carcinomas, including colorectal. In order to investigate the correlation between the presence of high-risk HPVs and Fascin, Id-1, and P-cadherin genes in human colorectal cancer (CRC) in the Syrian population, we examined the incidence of high-risk HPV types (16, 18, 31, 33 and 35) and their association with Fascin, Id-1 and P-cadherin expression. Materials and Methods: A total of 78 blocks from CRC Syrian patients were used in this study. These blocks were analyzed using polymerase chain reaction (PCR) and tissue microarray (TMA) analyses for the presence of high-risk HPVs and Fascin, Id-1 as well as P-cadherin expression, respectively. Results: We found that high-risk HPVs were present in 42 samples (53.84%), which represent the majority of invasive CRC cases; the most frequent high-risk HPV types in the Syrian population are 16, 33, 18, 35 and 31 respectively. Furthermore, the expression of E6 onco-protein of high-risk HPVs was found to be correlated with Fascin, Id-1 and P-cadherin expression/over-expression in the majority of CRC tissue samples. Conclusion : These data reveal that high-risk HPVs are present in human CRCs in the Syrian population, and their presence is associated with invasive and metastatic phenotype.


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