Submit Your Article CMED MEACR meeting
Home Print this page Email this page Users Online: 434
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2012  |  Volume : 1  |  Issue : 1  |  Page : 13-15

Cholinesterase in osteosarcoma


1 Department of Orthopaedics, Pt. B.D. Sharma, PGIMS, Rohtak, Haryana, India
2 Department of Biochemistry, Pt. B.D. Sharma, PGIMS, Rohtak, Haryana, India

Correspondence Address:
Simmi Kharb
#1447, Sector-1, Rohtak - 124 001, Haryana
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2278-0513.95013

Rights and Permissions

Background: Several biochemical markers have been proposed to have diagnostic and prognostic value in the management of osteosarcoma. Cholinesterase affects cell proliferation, differentiation and responses to various insults, including stress, and might have functional role in bone tissues. Status of serum cholinesterase levels in osteosarcoma is not clear. Hence, the present study was planned to analyze the status of cholinesterase in patients with osteosarcoma. Methods: Serum cholinesterase levels were analyzed in 30 cases of osteosarcoma and 30 patients with musculoskeletal pain. Results: Serum calcium and alkaline phosphatase levels were significantly raised with osteosarcoma (group I) as compared with controls (group II) (P<0.01). Serum phosphorus levels were lower in group I as compared with group II and the difference was not statistically significant (P>0.05). Serum cholinesterase levels were decreased in osteosarcoma patients (group I) as compared with the patients with musculoskeletal pain (group II, P<0.05). Conclusion: Findings of low levels of serum cholinesterase levels in the present study demonstrate that cholinesterase secreted by osteoblasts is consumed in bone formation and tumorigenesis.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2119    
    Printed145    
    Emailed1    
    PDF Downloaded192    
    Comments [Add]    

Recommend this journal